Meta-analysis of clinical efficacy of Dalitong granules combined with proton pump inhibitor in the treatment of gastroesophageal reflux disease
Objective:To systemeticly evaluate the clinical efficacy and safety of Dalitong granules(达立通颗粒)combined with protonpump inhibitor in the treatment of gastroesophageal reflux disease(GERD).Methods:PubMed,EMbase,Cochrane Library,China Biomedical Literature Database(CBM),Chinese National Knowledge Infrastructure(CNKI),VIP Chinese Journal Database(VIP)and WanFang Data(WanFang Data)were searched.The search period was from the establishment of the database to May 2023.All randomized controlled trials(RCT)on Dalitong granules combined with proton pump inhibitor in the treatment of gastroesophageal reflux disease were searched.According to inclusion criteria and exclusion criteria,multiple researchers independently screened literatures,extracted data,and conducted bias risk assessment for included literatures.Meta-analysis was performed using RevMan 5.3 software.Results:Screening results showed that a total of 8 randomized controlled trials(including 812 patients)were included in this study,including 423 cases in the experimental group(Dalitong granules combined with proton pump inhibitor group)and 389 cases in the control group(proton pump inhibitor group).The results of Meta-analysis showed that compared with proton pump inhibitor alone,Dalitong granules combined with proton pump inhibitor could significantly improve the clinical efficacy of gastroesophageal reflux disease treatment[RR=1.24,95％CI(1.16,1.33),P＜0.000 01],and the effect of repairing esophageal mucosa under gastroscopy was better[RR=1.19,95％CI(1.09,1.30),P＜0.000 1];There was no significant difference in the incidence of adverse reactions between the two groups[RR=0.97,95％GI(0.45,2.06),P=0.93].Conclusion:Current evidence shows that compared with proton pump inhibitor alone,Dalitong granules combined with proton pump inhibitor has a significant effect in the treatment of gastroesophageal reflux disease,which can better relieve the symptoms of gastroesophageal reflux disease and repair the esophageal mucosa.However,due to the limited quality and quantity of the included studies,more high-quality and large sample randomized controlled clinical trials are needed to verify the above conclusion.
万方数据
维普
