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中医"正气存内,邪不可干"与机体内源性抗损伤反应的相关性初探

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内源性抗损伤反应是生物机体清除体内细菌病毒、维持机体内环境稳态的重要自我保护机制.其通过诱导相关保护蛋白,使机体自身防御系统产生对抗损伤的触发物质和中介物质,从而激活金属硫蛋白、热休克蛋白、一氧化氮、丝裂素活化蛋白激酶等效应物质及相关信号通路,提高机体对疾病的适应能力与抗损伤能力,是防治疾病、维持机体自身稳态的重要途径.中医"正气存内,邪不可干"理论是对人体发挥抗病、祛邪、调节、修复功能和机体对外界刺激适应能力的高度概括,阐明了在疾病的发生发展过程中正气发挥着主导作用,正气不足是疾病发生的先决条件.而且正气发挥正常的生理功能要满足"足""通""和"三个基本条件.内源性抗损伤反应与中医"正气存内,邪不可干"理论联系密切,都表明了正气不足、抵抗力下降是机体发病的前提条件,正气与抗损伤物质不能通达患病部位是机体发病的重要原因.本研究基于中医"正气存内,邪不可干"理论与机体内源性抗损伤反应的防治特点、防治通路及物质基础等为契入点,研究机体内源性抗损伤反应与中医"正气存内,邪不可干"理论的相关性,揭示其在疾病预防和诊疗过程中的重要作用.
A Preliminary study on the correlation between traditional Chinese medicine's"Keeping healthy Qi and preventing evil pathogens"and the body's endogenous anti-injury response
Endogenous anti-injury response is an important self-protection mechanism for the organism to eliminate bacteria and viruses in the body and maintain the homeostasis of the organism.By inducing related protective proteins,it makes the body's own defense system produce trigger substances and intermediary substances to fight damage,thereby activating effector substanc-es such as metallothionein,heat shock protein,nitric oxide,mitotin-activated protein kinase and related signaling pathways,improving the body's ability to adapt to diseases and resist damage,which is an important way to prevent and control diseases and maintain the body's homeostasis.The traditional Chinese medicine theory of"Keeping healthy Qi(气)and preventing evil pathogens"is a high generaliza-tion of the human body to play the function of disease resistance,exorcism,regulation,repair and the body's ability to adapt to extemal stimuli,clarifying that healthy Qi plays a leading role in the occurrence and development of diseases,and the deficiency of healthy Qi is a prerequisite for the occurrence of diseases.And the normal physiological function of positive Qi should meet the three basic conditions of"sufficiency","passibility"and"harmony".Endogenous anti-injury response is closely related to the theory of traditional Chinese medicine"Keeping healthy Qi and preventing evil pathogens",which indicates that the deficiency of healthy Qi and the decline of resistance are the preconditions for the disease of the body,and the important reason for the disease is that healthy Qi and anti-injury substances cannot reach the diseased site.Based on the TCM theory of"Keeping healthy Qi and preventing evil pathogens"and the prevention and control charac-teristics,prevention and control pathways and material basis of the body's endogenous anti-injury response,this paper studies the correla-tion between the body's endogenous anti-injury response and the TCM theory of"Keeping healthy Qi and preventing evil pathogens",and reveals its important role in disease prevention and diagnosis and treatment.

Endogenous anti-injury responseKeeping healthy Qi and preventing evil pathogensAnti-damage substance

徐世红、赵军、王兴盛、王培鑫、姜朝阳、王小强

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甘肃省中医院,甘肃 兰州,730050

甘肃中医药大学,甘肃 兰州,730000

内源性抗损伤反应 正气存内 邪不可干 抗损伤物质

2024

中医临床研究
中华中医药学会

中医临床研究

影响因子:0.839
ISSN:1674-7860
年,卷(期):2024.16(27)