Exploring the medication rule and action mechanism of the Xiexin decoction in the treatment of chronic atrophic gastritis based on data mining and network pharmacology
Objective:To explore the medication rule and action mechanism of the Xiexin decoction(泻心汤)in the treatment of chronic atrophic gastritis(CAG).Methods:Relevant literature was retrieved from CNKI and Wanfang databases to establish a database.Traditional Chinese medicine inheritance support system was used to analyze and summarize medication rules,and obtain core tripartite medicines.Traditional Chinese medicine systems pharmacology database and analysis platform was used to retrieve the main active ingredients and targets,and GeneCards database and OMIM database were used to search for CAG disease targets.The intersection of the active components and the disease targets was taken to draw the Venn diagram.Visualization of medicine-active ingredient-intersection target regulatory network was carried out in Cytoscape.GO function and KEGG signal pathway enrichment analyses were performed by R language software.Results:A total of 195 articles were included,involving 199 prescriptions,among which 19 high-frequency medicines were used more than 20 times.The modified drugs were mainly Qi(气)-regulating drugs,blood-activating and stasis-removing drugs,etc..The core tripartite medicines were Banxia(Rhizoma Pinelliae)-Huangqin(Radix Scutellariae)-Huanglian(Rhizoma Coptidis),with 203 active ingredient targets,1 059 disease targets,and 83 intersecting targets.The main active ingredients were baicalin,quercetin,and locutin.According to protein-protein interaction network analysis,key targets included TP53,AKT1,TNF,IL-6,BCL2,etc..Through GO function enrichment analysis,2 160 entries were obtained,including the biological processes,cellular components,and molecular functions.KEGG pathway enrichment analysis revealed 159 signaling pathways.Conclusions:It was concluded that the key active ingredients of the core tripartite medicines Banxia-Huangqin-Huanglian in the treatment of CAG were baicalin,quercetin,locutin,etc.,that the key targets were TP53,AKT1,TNF,IL-6,BCL2,etc.,and that its role is mainly related to PI3K-Akt signaling pathway,IL-17 signaling pathway,TNF signaling pathway,cell apoptosis pathway,and cancer-related pathway.It can be seen that the Xiexin decoction has the characteristics of multiple components,multiple targets,and multiple pathways in the treatment of CAG,which provides a theoretical basis for the treatment of CAG with the Xiexin decoction.
Chronic atrophic gastritisThe Xiexin decoctionData miningMedication ruleMechanism research
万方数据
维普
