The medication rule of Professor HU Xiaomei in treating minimal residual leukemia based on data mining
Objective:To investigate the medication rule of Professor HU Xiaomei in the treatment of minimal residual leukemia(MRL)by traditional Chinese medicine inheritance support system(TCMISS,version 3.0),so as to summarize the differentiation and treatment methods of MRL.Methods:A total of 133 effective prescriptions of Professor HU Xiaomei for the treatment of MRL in outpatient were collected and input into TCMISS to establish a prescription database of Professor HU Xiaomei for the treatment of MRL.Results:By analyzing the symptoms of patients in the database,as well as four properties,five tastes,meridian-tropism,usage frequency,and prescription composition pattern of the medicines used,it was found that there were 14 commonly used medicines,includeing Fuling(Poria),Shanyao(Rhizoma Dioscoreae),Shanzhuyu(Fructus Corni),Baizhu(Atractylode),Zhi Gancao(Prepared Radix Glycyrrhizae),Mudanpi(Cortex Moutan),Chenpi(Pericarpium Citri Reticulatae),etc.Among the core medicine combinations,Fuling,Shanzhuyu,Shu Dihuang(Radix rehmanniae praeparata)and so on were mostly associated with Shanyao.Eight new prescriptions for treating MRL were obtained through cluster analysis.Conclusion:Through data mining methods such as text mining and association rule analysis,the prescription principle of HU Xiaomei in treating MRL is effectively summarized in this paper.The ideas of HU Xiaomei for treating MRL is based on syndrome differentiation,starting from pathological state of vital energy deficiency with pathogenic factor-lingering,and taking the methods of enforcing spleen and nourishing kidney,and strengthening vital energy to eliminate pathogenic factor.Liuwei Dihuang Wan(六味地黄丸)plus the Liujunzi decoction(六君子汤)is mainly used to nourish liver and kidney,and invigorate spleen and strengthen Qi.
Traditional Chinese medicine inheritance support systemMinimal residual leukemiaMedication rule
万方数据
维普
