首页|基于数据挖掘探讨《景岳全书·外科钤古方》用药规律

基于数据挖掘探讨《景岳全书·外科钤古方》用药规律

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目的:基于数据挖掘分析《景岳全书·外科钤古方》的用药规律与学术思想,为临床用药提供思路.方法:手工检索《景岳全书》关于外科的医案方药,通过Excel 2010、IBM® SPSS Statistics、IBM SPSS Modeler对相关医案中外科方药进行频次、性味归经、聚类分析及关联规则分析.结果:《景岳全书·外科钤古方》主要包括疮疡痈疽以及骨科相关疾病.本研究最终纳入314首处方,389味中药,累计用药2 210次.其中,频次大于10的中药有55味,占总频次的60.82%,主要有当归、生甘草、酒、大黄、人参等.四气以寒(121次)为主,五味以苦(161次)为主,归经以归肝经(161次)为主.聚类分析得到19组药物组合,主要有C1:当归、甘草;C2:生姜、黄芪、人参、白术、茯苓;C3:防风、白芷等.聚类分析中,频次排在前3位的药物组合为当归→黄芪、人参→茯苓、甘草→连翘,药物关联规则分析提示核心药物组合有人参→陈皮and白术、白术→陈皮and人参、人参→白术and黄芪.结论:《景岳全书·外科钤古方》重视脉诊,强调活血解毒治法,亦不忽视解表、行气、滋阴和燥湿之法,体现了张介宾(号景岳)论治外科疾病的学术思想,为现代临床治疗外科疾病提供参考.
The medication rules in Jingyue Quanshu·Waike Qian Gu Fang based on data mining
Objective:Based on data mining,the medication rules and academic ideas in Jingyue Quanshu·Waike Qian Gu Fang(《景岳全书·外科钤古方》)were explored to provide medication ideas for clinical practice.Methods:Medical records and prescriptions related to surgery diseases in Jingyue Quanshu(《景岳全书》)were manually searched out,and Excel 2010,IBM® SPSS Statistics and IBM SPSS Modeler were used to analyze the used frequency,medicinal properties,medicinal tastes,and meridian distribution of surgical prescriptions in relevant medical records,and the clustering analysis and association rule analysis were performed.Results:Jingyue Quanshu·Waike Qian Gu Fang mainly covers ulcers,carbuncles,and related orthopedic diseases.This study ultimately included 314 prescriptions,with 389 Chinese medicines and a cumulative used frequency of 2 210 times.Among them,there were 55 Chinese medicines used more than 10 times,accounting for 60.82%of the total used frequency,mainly including Danggui(Radix Angelicae Sinensis),Gancao(Radix Glycyrrhizae),liquor,Dahuang(Radix et Rhizoma Rhei),Renshen(Radix Ginseng),etc..The medicinal property was mainly cold(121 times);the medicinal flavor was mainly bitter(161 times);the meridian distribution was mainly the liver meridian(161 times).The cluster analysis gained 19 medicine combinations such as C1:Danggui,Gancao;C2:Shengjiang(Rhizoma Zingiberis Recens),Huangqi(Radix Astragali),Renshen,Baizhu(Atractylode),Fuling(Poria);C3:Fangfeng(Radix Saposhnikoviae),Baizhi(Radix Angelicae Dahuricae).In the cluster analysis,the top three medicine combinations were Danggui → Huangqi,Renshen → Fuling,Gancao → Lianqiao(Forsythia suspensa).The core medicine combinations in medicine association rule analysis included Renshen → Chenpi(Pericarpium Citri Reticulatae)and Baizhu,Baizhu →Chenpi and Renshen,Renshen → Baizhu and Huangqi.Conclusion:Jingyue Quanshu·Waike Qian Gu Fang attaches great importance to pulse diagnosis,emphasizes the treatment method of promoting blood circulation and detoxification,and does not ignore the methods of relieving external symptoms,promoting Qi(气)circulation,nourishing Yin(阴),and drying dampness.It reflects ZHANG Jiebin's academic ideas on the treatment of surgical diseases,and provides reference for modern clinical treatment of surgical diseases.

Jingyue QuanshuMedication ruleAcademic thoughtData mining

刘乐诗、余阗

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广州中医药大学第四临床医学院,广东 深圳,518000

广东省深圳市中医院,广东 深圳,518000

《景岳全书》 用药规律 学术思想 数据挖掘

2024

中医临床研究
中华中医药学会

中医临床研究

影响因子:0.839
ISSN:1674-7860
年,卷(期):2024.16(28)