A Meta-analysis of therapeutic effects of meibomian gland massage plus aerosol fumigation on meibomian gland dysfunction-related dry eye
Objective:To systematically evaluate the therapeutic effect of meibomian gland massage plus aerosol fumigation on meibomian gland dysfunction-related dry eye.Methods:Six databases including CNKI,Wanfang,VIP,PubMed,Embase and Web of Science were searched by computer to retrieve the literature published from January 2018 to September 2023 on clinical randomized controlled trials of treating meibomian gland dysfunction-related dry eye.Among them,the control group was treated in conventional Western medicine,and the trial group was treated by meibomian gland massage plus aerosol fumigation on the basis of the treatment in the control group.Duplicate literature was eliminated,and layers of screening was conducted to extract relevant data and assess risk bias.Review Manager 5.4 and Stata 16 were used to conduct a Meta-analysis on 6 outcome indicators,including ocular surface disease index(OSDI)score,tear film break-up time(BUT),tear Schirmer I test(SIT),corneal fluorescein staining(CFS)score,meibomial gland yielding secretion scale(MGYSS)score,and clinical efficacy.Results:A total of 25 randomized controlled trial studies were included,with 2 732 meibomian gland dysfunction-related dry eye patients.According to results of the Meta-analysis,compared with the control group,clinical efficacy(OR=5.84,95％CI:4.24-8.04,Z=10.82,P＜0.000 01),BUT(SMD=1.27,95％CI:0.84-1.71,Z=5.70,P＜0.000 01),SIT(SMD=1.20,95％CI:0.35～2.04,Z=2.78,P=0.006)in the trial group were improved obviously,and OSDI score(SMD=-1.43,95％CI:-2.19--0.67,Z=3.68,P=0.000 2),CFS score(SMD=-0.96,95％CI:-1.51--0.42,Z=3.46,P=0.000 5),and MGYSS score(SMD=-1.99,95％CI:-3.05--0.93,Z=3.68,P=0.000 2)were decreased.Conclusion:Compared with conventional Western medicine treatment alone,the intervention of meibomian gland massage plus aerosol fumigation shows a better clinical effect on meibomian gland dysfunction-related dry eye,and can better ameliorate patients'self-conscious symptoms and signs.
Meibomian gland massageAtomizing fumigationDry eye associated with meibomian gland dysfunctionMeta-analysis
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