首页|刘立教授清肝宁心法治疗围绝经期抑郁症(肝郁肾虚证)的经验探讨

刘立教授清肝宁心法治疗围绝经期抑郁症(肝郁肾虚证)的经验探讨

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围绝经期抑郁症是围绝经期女性常见的一种神志类疾病,以情绪低落、忧郁焦虑为主要特征,其西医病因及发病机制目前仍不明晰,激素和抗抑郁类药物是当前西医治疗本病的主要方案,但致癌风险高,存在一定的局限性,且不良反应众多.中医药治疗精神疾病有极大的优势,可在提高神经递质水平、调节神经内分泌激素、抑制神经细胞凋亡等方面发挥显著作用,从而减轻围绝经期抑郁症患者的抑郁症状、改善预后,且不良反应小、疗效较好,在临床中更受患者青睐.导师分析本病的病因和核心病机,进一步确定采用清肝宁心法,从肝、肾二脏入手治疗围绝经期抑郁症(肝郁肾虚证).肝、肾两脏通过脑、髓紧密联系,与精神心理类疾病相通,可通过调节相关激素水平恢复下丘脑-垂体-卵巢(Hypothalamic-Pituitary-Ovarian,HPO)轴正常功能,从而维持女性体内神经、内分泌系统的动态平衡.此方法对围绝经期抑郁症具有显著疗效,值得进一步探讨.
Professor LIU Li's experience in treating perimenopausal depression(the liver depression and kidney deficiency syndrome)by the liver clearing and heart calming method
Perimenopausal depression(PMD)is a common mental disease in perimenopausal women,mainly characterized by low mood,depression and anxiety.The etiology and pathogenesis of the disease are still unclear in Westem medicine.Hormone and antidepressant drugs are the main treatment programs for the disease in Western medicine at present,but their carcinogenic risk is high,with certain limitations,and such drugs have many adverse reactions.Traditional Chinese medicines has great advantages in the treatment of mental diseases.Traditional Chinese medicine plays a considerable role in improving the level of neurotransmitters,regulating neuroendocrine hormones,inhibiting nerve cell apoptosis,etc.,thus reducing the depressive symptoms of PMD patients and improving the prognosis,with few adverse reactions and significant curative effects.Many patients are more inclined to take Chinese medicines in the treatment process.The supervisor analyzes the etiology and core pathogenesis of the disease,and further determines the use of the clearing liver and calming heart method to treat perimenopausal depression(the liver depression and kidney deficiency syndrome)from the liver and kidney viscera.The supervisor believes that the liver and kidney are closely connected with mental and psychological diseases through the brain and pulp,and can restore the normal function of the HPO axis by adjusting related hormone levels,so as to maintain the dynamic balance of the nervous and endocrine systems in the female body.This method has a significant effect on perimenopausal depression and deserves further study.

Perimenopausal depressionClearing liver and calming heartLiver depression and kidney deficiency syndromeHypothalamic-pituitary-ovarian axisExperience summary

边蕾、刘立、赵雪莉

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甘肃中医药大学,甘肃 兰州,730000

围绝经期抑郁症 清肝宁心 肝郁肾虚证 下丘脑-垂体-卵巢轴 经验总结

2024

中医临床研究
中华中医药学会

中医临床研究

影响因子:0.839
ISSN:1674-7860
年,卷(期):2024.16(29)