中医临床研究2024,Vol.16Issue(29) :114-123.DOI:10.3969/j.issn.1674-7860.2024.29.022

自血穴位注射治疗慢性阻塞性肺疾病的Meta分析

A Meta-analysis of treating chronic obstructive pulmonary disease by self-blood acupoint injection

王珊珊 蔡成森 于健健 司雪杰 王珺 陈文靖
中医临床研究2024,Vol.16Issue(29) :114-123.DOI:10.3969/j.issn.1674-7860.2024.29.022

自血穴位注射治疗慢性阻塞性肺疾病的Meta分析

A Meta-analysis of treating chronic obstructive pulmonary disease by self-blood acupoint injection

王珊珊 1蔡成森 2于健健 2司雪杰 2王珺 2陈文靖2
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作者信息

  • 1. 山东中医药大学,山东 济南,250014
  • 2. 山东中医药大学第二附属医院,山东 济南,250001
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摘要

目的:评价自血穴位注射治疗慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Disease,COPD)的临床有效性.方法:检索中国知网、PubMed等数据库从建库至2023年10月8日的自血穴位注射治疗COPD的临床随机对照试验研究,由两位研究人员分别对文献进行筛选,提取数据,并对入选的文献进行偏倚风险评估,然后使用RevMan 5.4进行Meta分析.结果:共纳入22个随机对照试验研究,共计1881例患者.Meta分析结果显示:与对照组相比,加用自血疗法能提高临床总有效率[OR=3.73,95%CI(2.79,4.98),P<0.000 01],延长 6 min 步行试验(6-minute Walk Test,6 WMT)[MD=34.21,95%CI(24.92,43.51),P<0.000 01],改善慢性阻塞性肺疾病评估测试(COPD Assessment Test,CAT)评分[MD=-3.86,95%CI(-5.20,-1.26),P<0.000 01],提高肺功能指标如用力肺活量(Forced Vital Capacity,FVC)[MD=0.45,95%CI(0.42,0.49),P<0.000 01]等19个结局指标,组间差异具有统计学意义.结论:自血疗法治疗COPD可显著提高临床有效率,改善6 WMT,降低中医证候积分、圣乔治呼吸问题问卷(St.George's Respiratory Questionnaire,SGRQ)评分、CAT评分等,改善肺功能,减少炎症指标,提高患者的免疫功能和生活质量.

Abstract

Objective:To evaluate the clinical effectiveness of self-blood acupoint injection in the treatment of chronic obstructive pulmonary disease(COPD).Methods:Databases such as China Knowledge and Pubmed were searched to retrieve studies on the clinical randomized controlled trials of treating COPD by self-blood acupoint injections from the establishment of the databases to October 8,2023.Two researchers severally screened the literature,extracted the data,and assessed the risk of bias for the selected ones,and then performed a Meta-analysis by RevMan 5.4.Results:A total of 22 studies with 1 881 patients were included in the study,and the results of the Meta-analysis showed that compared with the control group,self-blood acupoint injection increased the total clinical efficiency[OR=3.73,95%CI(2.79,4.98),P<0.000 01]and prolonged 6 WMT distances[MD=34.21,95%CI(24.92,43.51),P<0.000 01],ameliorated CAT score[MD=-3.86,95%CI(-5.20,-1.26),P<0.000 01],and improved lung function indexes such as FVC[MD=0.45,95%CI(0.42,0.49),P<0.000 01],a total of 19 outcome indexes,and the differences were statistically significant between groups.Conclusions:Self-blood acupoint injection in the treatment of COPD can significantly improve 6 WMT distances,decrease TCM syndrome scores,SGRQ score and CAT score,improve the lung function,reduce the inflammatory index levels,and improve the immune function and the quality of life of the patients.

关键词

慢性阻塞性肺疾病/自血穴位注射/Meta分析

Key words

Chronic obstructive pulmonary disease/Self-blood acupoint injection/Meta-analysis

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出版年

2024
中医临床研究
中华中医药学会

中医临床研究

影响因子:0.839
ISSN:1674-7860
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