首页|自血穴位注射治疗慢性阻塞性肺疾病的Meta分析

自血穴位注射治疗慢性阻塞性肺疾病的Meta分析

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目的:评价自血穴位注射治疗慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Disease,COPD)的临床有效性.方法:检索中国知网、PubMed等数据库从建库至2023年10月8日的自血穴位注射治疗COPD的临床随机对照试验研究,由两位研究人员分别对文献进行筛选,提取数据,并对入选的文献进行偏倚风险评估,然后使用RevMan 5.4进行Meta分析.结果:共纳入22个随机对照试验研究,共计1881例患者.Meta分析结果显示:与对照组相比,加用自血疗法能提高临床总有效率[OR=3.73,95%CI(2.79,4.98),P<0.000 01],延长 6 min 步行试验(6-minute Walk Test,6 WMT)[MD=34.21,95%CI(24.92,43.51),P<0.000 01],改善慢性阻塞性肺疾病评估测试(COPD Assessment Test,CAT)评分[MD=-3.86,95%CI(-5.20,-1.26),P<0.000 01],提高肺功能指标如用力肺活量(Forced Vital Capacity,FVC)[MD=0.45,95%CI(0.42,0.49),P<0.000 01]等19个结局指标,组间差异具有统计学意义.结论:自血疗法治疗COPD可显著提高临床有效率,改善6 WMT,降低中医证候积分、圣乔治呼吸问题问卷(St.George's Respiratory Questionnaire,SGRQ)评分、CAT评分等,改善肺功能,减少炎症指标,提高患者的免疫功能和生活质量.
A Meta-analysis of treating chronic obstructive pulmonary disease by self-blood acupoint injection
Objective:To evaluate the clinical effectiveness of self-blood acupoint injection in the treatment of chronic obstructive pulmonary disease(COPD).Methods:Databases such as China Knowledge and Pubmed were searched to retrieve studies on the clinical randomized controlled trials of treating COPD by self-blood acupoint injections from the establishment of the databases to October 8,2023.Two researchers severally screened the literature,extracted the data,and assessed the risk of bias for the selected ones,and then performed a Meta-analysis by RevMan 5.4.Results:A total of 22 studies with 1 881 patients were included in the study,and the results of the Meta-analysis showed that compared with the control group,self-blood acupoint injection increased the total clinical efficiency[OR=3.73,95%CI(2.79,4.98),P<0.000 01]and prolonged 6 WMT distances[MD=34.21,95%CI(24.92,43.51),P<0.000 01],ameliorated CAT score[MD=-3.86,95%CI(-5.20,-1.26),P<0.000 01],and improved lung function indexes such as FVC[MD=0.45,95%CI(0.42,0.49),P<0.000 01],a total of 19 outcome indexes,and the differences were statistically significant between groups.Conclusions:Self-blood acupoint injection in the treatment of COPD can significantly improve 6 WMT distances,decrease TCM syndrome scores,SGRQ score and CAT score,improve the lung function,reduce the inflammatory index levels,and improve the immune function and the quality of life of the patients.

Chronic obstructive pulmonary diseaseSelf-blood acupoint injectionMeta-analysis

王珊珊、蔡成森、于健健、司雪杰、王珺、陈文靖

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山东中医药大学,山东 济南,250014

山东中医药大学第二附属医院,山东 济南,250001

慢性阻塞性肺疾病 自血穴位注射 Meta分析

2024

中医临床研究
中华中医药学会

中医临床研究

影响因子:0.839
ISSN:1674-7860
年,卷(期):2024.16(29)