The medication rule of TCM medicine in treating psoriasis by regulating ferroptosis based on network pharmacology and data mining technology
Objective:In this paper,network pharmacology and data mining technology was mainly used to explore the medication rule of TCM medicine on psoriasis by regulating ferroptosis,so as to provide ideas for the related research on psoriasis.Methods:The GeneCards,GeneCLiP3 and FerrDb databases were used to obtain the strong related targets of ferroptosis,and GeneCards and DisGeNET databases were used to gain the psoriasis disease targets.The intersection of the two was taken to obtain the relevant targets of ferroptosis in psoriasis.The protein-protein interaction analysis was performed on the target of ferroptosis in psoriasis,and the targets with degree values of not less than 2 times the median were selected.Related compounds and TCM medicine were obtained by TCMSP.Cytoscape 3.10.1 software was used to build potential target-compound network diagram,and target-compound-TCM medicine network diagram.Results:A total of 227 targets related to ferroptosis in psoriasis were obtained,and 48 potential targets with degree values of no less than 108 were identified.A total of 37 compounds and 784 kinds of TCM medicine were screened.Conclusion:Starting from the targets of psoriasis and ferroptosis,this study explores the TCM medicine and the medication rule in regulating ferroptosis in psoriasis,and the related action mechanism of TCM medicine on ferroptosis in psoriasis,which can provide reference for the related research of ferroptosis in psoriasis.
万方数据
维普
