Revealing the medication regulations of national patent TCM compound preparations in the treatment of thyroid nodules through data mining
Objective:To explore the medication rules of traditional Chinese medicine compound preparations in the treatment of thyroid nodules in the National Patent Network through data mining.Methods:After logging in the National Patent Network(http://epub.cnipa.gov.cn)to construct a search formula,the patents of traditional Chinese medicine compound preparations for the treatment of thyroid nodules published in the National Patent Network from the establishment of the database to March 1,2024 were searched through advanced search functions.The traditional Chinese medicine compound prescriptions that met the requirements were recorded one by one in to EXCEL as the original data.After data processing,the frequency of drug use,drug efficacy categories,taste and meridian tropism,drug toxicity were statistically analyzed.At the same time,IBM SPSS Modeler 18,IBM SPSS Statistics 26 were used for association rules and cluster analysis of drugs.Results:A total of 86 TCM compound preparations for the treatment of thyroid nodules were included.After screening,a total of 274 drugs were obtained.Among them,24 Chinese medicines were used more than 10 times.Xiakucao(Spica Prunellae)was used most frequently,36 times,followed by Zhebeimu(Bulbus Fritillariae Thunbergii),29 times,and the third was Muli(Concha Ostreae),27 times.In terms of drug taste and meridian tropism,the four Qi(气)of the drug were mostly cold,with a total of 441 times.The five flavors were dominated by bitter taste,with 555 times.The meridian tropism was mostly liver meridian,followed by lung meridian and spleen meridian.In terms of drug toxicity,a total of 25 kinds of toxic drugs were used,including 2 kinds of large toxic drugs,15 kinds of toxic drugs and 8 kinds of small toxic drugs.The most frequently used toxic drugs were Banxia(Rhizoma Pinelliae),which were used 22 times,followed by Huangyaozi(Rhizoma Dioscoreae).A total of 7 drug combinations were obtained by association rule analysis of high-frequency drugs,and 3 effective clustering prescriptions were obtained by cluster analysis.Conclusion:In the National Patent Network,many doctors pay more attention to the treatment of liver,lung,spleen and other organs in the treatment of thyroid nodules.The drugs are mainly used for resolving phlegm,clearing heat,promoting blood circulation and removing blood stasis,and tonifying deficiency,taking into account the use of drugs for regulating Qi and relieving depression.At the same time,there are some toxic drugs and insect drugs,which provide reference for the clinical treatment of thyroid nodules and the development and application of new prescriptions.
Data miningNational patentTraditional Chinese medicine compound preparationThyroid noduleSimple goiter
万方数据
维普
