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《临证指南医案》"和阳法"用药规律研究

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目的:运用数据挖掘方法研究《临证指南医案》"和阳法"相关病案的用药规律及组方特点.方法:整理《临证指南医案》中的"和阳法"相关病案,建立病种、证型及药物数据库,通过统计学分析方法如数据透视法、关联规则分析、聚类分析等研究相关数据特点.结果:共纳入45首处方,涉及药物79味,主治病种24个,证型16个.使用频次居前5位的药物为生地黄、阿胶、白芍、茯神、麦冬.由药味统计可知,使用最多的药味为甘味,归经多归肝经、肾经、心经、肺经.高频药物使用频次较高的前5个病种依次为吐血病、肝风病、产后病、崩漏病、三消病,高频药物使用频次较高的前5个证型依次为阴虚风动证、阴虚阳亢证、肝风内动证、阴虚内热证、肝阴不足证.经关联规则分析获得两组核心药对:白芍-黄连和生地黄-麦冬.通过聚类分析获得2对核心药对,C1组:黄连、白芍;C2组:麦冬、生地黄、阿胶.结论:《临证指南医案》"和阳法"主要通过滋阴药物来制约体内异常变动的阳气,从而治疗阴阳不和的疾病,滋养阴阳贯穿疾病治疗始终,为"和阳法"的核心内容.
A study on the medication rule of harmonizing Yang method in Linzheng Zhinan Yi'an
Objective:To study the medication rules and prescription characteristics of harmonizing Yang(阳)method related medical records in Linzheng Zhinan Yi'an(《临证指南医案》)by data mining method.Methods:The relevant medical records of harmonizing Yang method in Linzheng Zhinan Yi'an were sorted out to establish the database of disease types,syndrome types and medicines.The characteristics of relevant data were studied by statistical analysis methods such as data perspective,association rule analysis,cluster analysis,etc.Results:A total of 45 prescriptions were included,involving 79 Chinese medicines,24 diseases and 16 TCM syndrome types.The top 5 most frequently used medicines were Dihuang(Radix Rehmanniae),Ejiao(Equus Asinus),Baishao(Paeonia lactiflora),Fushen(Poria cum Radix Pini)and Maidong(Radix ophiopogon).According to the statistics of medicinal flavour,the most used medicinal taste was sweet,and the medicines used were mainly absorbed by the liver meridian,kidney meridian,heart meridian and lung meridian.The top five diseases with high frequency treated with high-frequency medicines were hematemesis disease,liver wind disease,postpartum disease,uterine bleeding disease,and Sanxiao(三消)disease.The top five syndrome types with high frequency treated with high-frequency medicines were the Yin(阴)deficiency and wind movement syndrome,the Yin deficiency and Yang(阳)hyperactivity syndrome,the liver wind internal movement syndrome,the Yin deficiency and internal heat syndrome,and the liver Yin deficiency syndrome.Two core medicines pairs were obtained by association rule analysis:Baishao-Huanglian(Rhizoma Coptidis),Shengdihuang-Maidong.Two core medicines pairs were obtained by the cluster analysis,group C1:Huanglian,Baishao;Group C2:Maidong,Shengdihuang,Ejiao.Conclusion:The harmonizing Yang method in Linzheng Zhinan Yi'an mainly regulates the abnormal changes of Yangqi(阳气)in the body through nourishing Yin medicines,so as to treat diseases of Yin(阴)and Yang disharmony.The treatment method of nourishing Yin and Yang runs through the whole treatment of diseases,which is the core content of harmonizing Yang method.

Linzheng Zhinan Yi'anHarmonizing Yang methodData miningMedication rule

林妙娴、刘燕芳

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厦门市湖里区禾山街道社区卫生服务中心,福建 厦门,361015

《临证指南医案》 和阳法 数据挖掘 用药规律

2024

中医临床研究
中华中医药学会

中医临床研究

影响因子:0.839
ISSN:1674-7860
年,卷(期):2024.16(31)