A review on the action mechanism of TCM medicine in treating podocyte injury in diabetic nephropathy
Podocyte is an important part of glomerular filtration barrier,and its injury is closely related to the occurrence and development of diabetic nephropathy.A series of key signaling pathways involved in podocellular injury,such as PI3K/Akt,NF-κB,GSK-3β,TGF-β1,and Wnt β-catenin,played an important role in diabetic nephropathy,and the specific action mechanism of these signaling pathways in diabetic nephropathy is different.Their abnormalities may lead to the breakdown of the glomerular filtration barrier,further promoting the progression of diabetic nephropathy.In the study of TCM medicine intervention on diabetic nephropathy,it is found that TCM medicine monomer and compound can interfere with these signaling pathways through various ways,so as to treat podocyte injury.The action mechanism of TCM medicine is complex and diverse.They can directly inhibit or activate specific signaling pathways,or indirectly prevent podocyte damage by regulating oxidative stress,inflammation response and so on.The advantage of TCM medicine intervention on diabetic nephropathy lies in its multi-target and multi-pathway treatment characteristics.This multi-target,multi-pathway treatment can not only reduce the damage of podocytes more effectively,but also reduce the adverse reactions and drug resistance.Therefore,TCM medicine has a broad application prospect in the intervention on podocyte injury in diabetic nephropathy.
万方数据
维普
