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乳腺癌内分泌治疗引起的血管舒缩症状中西医研究进展

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内分泌治疗是激素受体阳性乳腺癌患者的主要治疗方法之一,治疗时长可达数年,相关不良反应复杂多样.血管舒缩症状是内分泌治疗主要的不良反应之一,主要表现为烘热汗出,是接受内分泌治疗的患者就诊的重要原因.缓解血管舒缩症状可增加患者对内分泌治疗的依从性,改善其生活质量,因此对血管舒缩症状的治疗日益受到重视.目前,由乳腺癌内分泌治疗引起的血管舒缩症状发病机制复杂,治疗手段多样.激素疗法在改善本病的症状方面效果显著,但不适合长期应用.非激素(如帕罗西汀、文拉法辛)疗法仍是公认的首要治疗措施,效果显著,但不能治愈本病,且伴有一定的不良反应.非药物治疗策略(如生活方式调整、心理干预等)常用于缓解程度较轻的血管舒缩症状,也可配合药物治疗.中医治疗法(中药、针灸、耳穴等)具有不良反应少、作用持久、针对性强等优势,为受血管舒缩症状困扰的乳腺癌患者提供更多的选择.本研究通过查阅近几年国内外关于乳腺癌内分泌治疗引起血管舒缩症状的研究,从中西医角度阐述其发病机制、治疗策略,为制定个体化的临床治疗方案提供理论参考,以提高接受内分泌治疗的乳腺癌患者的生活质量.
A review on vasomotor symptoms in breast cancer induced by endocrine therapy in traditional Chinese medicine and Western medicine
Endocrine therapy is one of the main treatment methods for patients with hormone receptor positive breast cancer,and the treatment duration can span several years,with a variety of complex and diverse adverse reactions.Vasomotor symptom(VMS)is one of the main adverse reactions of endocrine therapy,primarily manifesting as hot flashes and sweating,which is an important reason for patients undergoing endocrine therapy to seek medical attention.Alleviating VMS can increase the compliance of patients with endocrine therapy and improve their quality of life,so the treatment of VMS is increasingly valued.Currently,the pathogenesis of VMS induced by endocrine therapy for breast cancer is complex,and treatment methods are diverse.Hormone therapy is effective in ameliorating the symptoms of the disease,but is generally contraindicated for long-term use.Non-hormonal(such as paroxetine,venlafaxine)therapies are still recognized as the primary therapeutic measures with significant effects,but they can not fundamentally treat the disease and are accompanied by certain adverse reactions.Non-pharmacological therapeutic strategies(such as lifestyle adjustments and psychological interventions)are often used to alleviate mild VMS,and can also be used in conjunction with pharmacologic therapy.Traditional Chinese medicine therapies(such as Chinese medicine,acupuncture,auricular therapy)has the advantages of less adverse reactions,long-lasting effects,and strong specificity,providing more options for breast cancer patients troubled by VMS.By reviewing the recent domestic and international studies on VMS induced by endocrine therapy for breast cancer,this study elaborates its pathogenesis and therapeutic strategies from the perspectives of traditional Chinese medicine and Western medicine,so as to provide a theoretical reference for formulating individualized clinical treatment plans,thereby improving the quality of life of breast cancer patients undergoing endocrine therapy.

Hormone receptor positive breast cancerEndocrine therapyVasomotor symptomTraditional Chinese medicine and Western medicine researchReview

黄杰、黄挺

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浙江中医药大学附属杭州临床医学院,浙江 杭州,310007

杭州市中医院,浙江 杭州,310007

激素受体阳性乳腺癌 内分泌治疗 血管舒缩症状 中西医研究 综述

2024

中医临床研究
中华中医药学会

中医临床研究

影响因子:0.839
ISSN:1674-7860
年,卷(期):2024.16(32)