Chinese medicine plus 125Ⅰ seed implantation and targeted therapy in the treatment of advanced lung adenocarcinoma:one case report and literature review
This article presents one case of advanced lung adenocarcinoma treated by a combination therapy and includes a literature review.The patient is a 65-year-old female diagnosed with advanced lung adenocarcinoma,accompanied by severe emaciation(body mass index is 12.5 kg/m2)and multiple metastases to mediastinal lymph nodes and bones.The patient had received particle implantation and empirical treatment with the molecular targeted drug gefitinib.Initially,the lung lesions were stable,but 15 months later,the recur and progress in the lungs and distant metastasis occurred.Blood genetic testing revealed an epidermal growth factor receptor exon 19 deletion mutation(E19 del)and negative T790M.Because the patient could not tolerate conventional chemotherapy,molecular targeted drugs were continued to be used,accompanied by Chinese medicine plus particle implantation.After four months of combination therapy,chest CT showed that the lung lesions had reduced in size.The imaging results were evaluated,and the disease was considered as stable according to RECIST 1.1 evaluation results.This case demonstrates that Chinese medicine plus particle implantation and targeted drugs can prolong the progression-free survival of patients and reduce the local recurrence rate.Additionally,Chinese medicines have played a unique role in mitigating adverse reactions due to targeted therapy and radiotherapy and ameliorating the clinical symptoms of patients.The literature review indicates that Chinese medicine compound preparations can ameliorate the immune status of the body by modulating immune activity and inhibiting immune escape,providing significant advantages in prolonging the stable period of disease and improving the quality of life of advanced lung cancer patients.The treatment experience of this case further supports the effectiveness of Chinese medicines plus other therapies in the treatment of advanced lung adenocarcinoma,offering insights for clinical practice.
Traditional Chinese medicineAdvanced lung adenocarcinomaParticle implantationMolecular targeting drug
万方数据
