首页|基于数据挖掘浅析蔡圣朝治疗类风湿关节炎的用药规律

基于数据挖掘浅析蔡圣朝治疗类风湿关节炎的用药规律

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目的:采用数据挖掘技术总结蔡圣朝教授治疗类风湿关节炎的临床辨证经验及用药规律,进一步指导临床用药.方法:收集蔡圣朝教授2022年1月1日-12月31日类风湿关节炎医案,运用Excel、SPSS Statistics 27、SPSS Modeler 18对药物使用情况进行频数统计、关联规则分析及系统聚类分析等.结果:共纳入处方129首,涉及101味中药,其中蔡圣朝教授治疗类风湿关节炎的核心药物(用药频次≥ 15)有桂枝、甘草、桑枝、白芍、威灵仙、木瓜等共32味,核心药物药性主要为温、平、寒,药味主要为辛、甘、苦,主要归肝经、脾经、肺经.按功效分类,主要用药为补虚药、祛风湿药.关联规则分析挖掘出10组关联药物组合,聚类分析挖掘出7组药物组合.结论:蔡圣朝教授临床论治类风湿关节炎强调"审因论治"思想,治疗上以"补益肝肾、调理脾胃、益气养血,兼以祛风通络、散寒除湿、祛瘀化痰"为根本,对临床中药治疗类风湿关节炎具有参考意义.
A brief analysis of the medication rule of CAI Shengchao in the treatment of rheumatoid arthritis based on data mining
Objective:To summarize Professor CAI Shengchao's clinical syndrome differentiation experience and medication rules in the treatment of rheumatoid arthritis by data mining technique,so as to provide further guidance on clinical medication.Methods:Medical cases of Professor CAI Shengchao about the treatment of rheumatoid arthritis from 1 January to 31 December 2022 were collected to perform frequency statistics,association rule analysis and systematic clustering analysis of medication by Excel,SPSS Statistics 27 and SPSS Modeler 18.Results:A total of 129 prescriptions involving 101 Chinese medicines were included,among which 32 core medicines(with a frequency of not less than 15 times)used by Professor CAI Shengchao for treating rheumatoid arthritis included Guizhi(Ramulus Cinnamomi),Gancao(Radix Glycyrrhizae),Sangzhi(Ramulus Mori),Baishao(Radix Paeoniae Alba),Weilingxian(Radix et Rhizoma Clematidis),Mugua(Fructus Chaenomelis)and so on.The medicinal properties of core medicines were mainly warm,moderate and cold,the medicinal tastes were mainly pungency,sweet and bitter,which mainly were absorbed by liver meridian,spleen meridian and lung meridian.According to the efficacy classification,tonifying medicine and dispelling wind-dampness medicine were mainly used clinically.Ten associated medicine combinations were mined by association rule analysis,and seven core medicine combinations were mined by clustering analysis.Conclusion:Professor CAI Shengchao's clinical treatment of rheumatoid arthritis emphasizes the academic idea of judging the cause to cure the disease,and the treatment is based on the principles of tonifying liver and kidney,regulating spleen and stomach,and benefiting the vital energy and nourishing the blood,accompanied by the methods of dispelling wind to dredge collaterals,dispelling cold and removing dampness,and dispelling blood stasis and resolving the phlegm.It has some reference significance to the clinical treatment of rheumatoid arthritis in traditional Chinese medicine.

Rheumatoid arthritisParalysis syndromeData miningAssociation ruleClustering analysis

范凯悦、蔡圣朝

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安徽中医药大学,安徽 合肥,230031

安徽省针灸医院,安徽 合肥,230061

类风湿关节炎 痹证 数据挖掘 关联规则 聚类分析

2024

中医临床研究
中华中医药学会

中医临床研究

影响因子:0.839
ISSN:1674-7860
年,卷(期):2024.16(32)