首页|氟化工厂男性职业人群血清全氟辛烷磺酸与生殖激素水平的相关性研究

氟化工厂男性职业人群血清全氟辛烷磺酸与生殖激素水平的相关性研究

扫码查看
目的 探讨男性职业人群全氟辛烷磺酸(perfluorooctane sulfonate,PFOS)暴露与血清生殖激素水平间的关系.方法 2020年5月选择江苏某氟化工厂248名男性工人进行问卷调查,并检测血清中PFOS及生殖激素水平,运用单因素分析和多元线性回归模型分析血清PFOS水平与生殖激素水平之间的关系.结果 在氟化工厂男性工人中,血清PFOS平均浓度为(12.41±5.96)ng/mL,血清睾酮、雌二醇、黄体生成素、卵泡刺激素平均浓度分别为(3.66± 1.29)nmol/L、(0.27±0.11)nmol/L、(4.59±0.74)IU/L、(4.25±0.33)IU/L.以三分位数划分的 3 个血清 PFOS 浓度组的睾酮、雌二醇水平差异有统计学意义(均P<0.05),但不同PFOS浓度组的黄体生成素和卵泡刺激素水平差异无统计学意义(均P>0.05).此外,未发现不同年龄、体质量指数、吸烟及饮酒情况工人的生殖激素水平差异有统计学意义(均P>0.05).多元线性回归分析结果显示:血清PFOS水平与睾酮为负相关关系(β=-0.047,95%CI:-0.074~-0.020,P<0.05),与雌二醇也为负相关关系(β=-0.004,95%CI:-0.007~-0.002,P<0.05),但并未发现PFOS与黄体生成素、卵泡刺激素存在相关性(均P>0.05).结论 PFOS暴露可能通过影响睾酮、雌二醇水平对男性生殖健康产生影响.
Association between serum perfluorooctane sulfonate and reproductive hormone levels among male workers in a fluoride-produced plant
Objective To investigate the relationship between perfluorooctane sulfonate(PFOS)exposure and serum reproductive hormone levels in male workers.Methods In May 2020,248 male workers from a fluoride-produced plant in Jiangsu were studied.The questionnaire survey was done,and serum PFOS and reproductive hormone levels were measured.One-way analysis of variance and multiple linear regression model were used to analyze the association between serum PFOS levels and reproductive hormone levels.Results Among these male workers,the serum PFOS level was(12.41±5.96)ng/mL,while the serum testosterone(T),estradiol(E2),luteinizing hormone(LH),and follicle-stimulating hormone(FSH)levels were(3.66±1.29)nmol/L,(0.27±0.11)nmol/L,(4.59±0.74)IU/L,and(4.25±0.33)IU/L,respectively.There were significant differences in testosterone and estradiol levels among the three serum PFOS concentration groups divided by tertiles(P<0.05),but no significant differences in luteinizing hormone and follicle-stimulating hormone levels(P>0.05).In addition,no significant differences were found between reproductive hormone levels among workers of different ages,body mass index,smoking,and drinking status(P>0.05).The results of multiple linear regression analysis showed that serum PFOS was negatively correlated with T(b=-0.047,95%CI:-0.074--0.020,P<0.05)and E2(b=-0.004,95%CI:-0.007--0.002,P<0.05),and no correlation with luteinizing hormone or follicle-stimulating hormone(P>0.05).Conclusions PFOS exposure may affect male reproductive health by influencing testosterone and estradiol levels.

perfluorooctane sulfonatereproductive hormonetestosteroneestradiolluteinizing hormonefollicle-stimulating hormone

李婷、黄季艳、仇梁林

展开 >

南通大学公共卫生学院,江苏 南通 226019

南通市崇川区疾病预防控制中心,江苏 南通 226001

血清 全氟辛烷磺酸 生殖激素 睾酮 雌二醇 黄体生成素 卵泡刺激素

江苏省高校自然科学研究项目南通市基础科学研究计划

18KJB330004JC2019021

2024

职业卫生与应急救援
上海市职业安全健康研究院,上海市化工职业病防治院

职业卫生与应急救援

CSTPCD
影响因子:0.515
ISSN:1007-1326
年,卷(期):2024.42(1)
  • 28