复方白葛胶囊的质量标准研究
Study on the Quality Standard of Fufang Bafge Capsules
施栋磊 1曹云台 1朱华旭 1郭立玮1
作者信息
- 1. 南京中医药大学中医药研究院,南京,210029
- 折叠
摘要
目的 建立复方白葛胶囊的质量标准.方法 采用薄层色谱法对处方中白芍、川芎、葛根3味中药进行定性鉴另,采用高效液相色谱法对制剂中的芍药苷进行定量测定.结果 TLC法能定性检出白芍、川芎、葛根,斑点清晰,且阴性对照无干扰;HPLC法测定芍药苷在0.061 7～0.987 5 μg范围内线性关系良好,平均加样回收率为98.80%,RSD=2.01%(n=9).结论 所建立的定性、定量检测方法 操作简便、结果 准确可靠、重现性好,能有效地控制复方白葛胶囊的质量.
Abstract
Objective To establish a quality standard for Fufang Baige Capsules (FBC). Methods The qualitative identification of Radix Paeoniae Alba, Rhizoma Chuanxiong and Radix Puerariae Lobatae in FBC was carried out by TLC, and the content of paeoniflorin was determined by HPLC. Results The relevant spots of Radix Paeoniae Alba, Rhizoma Chuanxiong and Radix Puerariae Lobatae on TLC plates were clear without the interference of the blank control. The content of paeoniflorin showed a good linearity in the range of 0. 06172 ~0. 9875 μg . The average recovery was 98. 80 % and RSD was 2. 01 %. Conclusion These qualitative and quantitative detection methods were simple, accurate, reliable and reproducible, andean be effectively used for the quality control of Fufang Baige Capsules.
关键词
复方白葛胶囊/白芍/川芎/葛根/芍药苷/TLC/HPLC/质量标准Key words
Fufang Baige Capsules/Radix Paeoniae Alba/Rhizoma Chuanxiong/Radix Puerariae Lobatae/Paeoniflorin/TLC/HPLC/Quality standard引用本文复制引用
出版年
2009
国家科技期刊平台
NSTL
维普
万方数据