首页|银连含漱液防治鼻咽癌放疗后急性放射性口咽黏膜炎的临床疗效观察

银连含漱液防治鼻咽癌放疗后急性放射性口咽黏膜炎的临床疗效观察

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目的 观察银连含漱液防治鼻咽癌放疗引起的急性放射性口咽黏膜炎的临床疗效.方法 将 32 例初次行放疗的鼻咽癌患者随机分为试验组(19 例)和对照组(13 例),两组在放疗、化疗的基础上,试验组予银连含漱液漱口,对照组予生理盐水漱口.观察两组患者干预前后严重急性放射性口咽黏膜炎的发生率,出现口咽部不适、口咽部疼痛的时间和程度(NRS评分)、生活质量评分(QOL-NPC评分)、出现放疗毒副作用(SE-QOL-NPC评分)及口干症状(SE1 评分)的时间及程度.结果 放疗至第 6 周时,试验组Ⅲ级及以上的放射性口咽黏膜炎的发生率显著低于对照组(P＜0.001);放疗结束后 1 个月,试验组I级及以上的放射性口咽黏膜炎的发生率显著低于对照组(P＜0.001).从放疗第 2 周开始,试验组咽部不适NRS评分低于对照组(P＜0.05);从放疗第 4 周开始口腔及口咽部疼痛NRS评分低于对照组(P＜0.05);从放疗第 5 周开始试验组SE1 评分高于对照组(P＜0.05);在放疗结束后 1 个月,试验组咽部不适NRS评分、口腔及口咽部疼痛NRS评分低于对照组(P＜0.001),QOL-NPC评分、SE-QOL-NPC评分和SE1 评分均高于对照组(P = 0.05 或P＜0.05).结论 鼻咽癌患者在放疗期间使用银连含漱液,可以显著减少严重的急性放射性口咽黏膜炎的发生,有效延迟和缓解急性放射性口咽黏膜炎的相关症状,提高患者放疗期间的生活质量,且在放疗结束 1 个月后,对急性放射性口咽黏膜炎仍有较好的疗效.
Clinical Observation of Yinlian Gargle in the Prevention and Treatment of Acute Radiation-Induced Oropharyngeal Mucositis After Nasopharyngeal Carcinoma Radiotherapy
Objective To observe the clinical efficacy of Yinlian Gargle in the treatment of acute radiation-induced oropharyngeal mucositis after nasopharyngeal carcinoma radiotherapy.Methods Thirty-two patients with nasopharyngeal carcinoma,who had received first radiation,were randomly split into two groups:the trial group(19 cases)and the control group(13 cases).After all groups were treated with radiotherapy and chemotherapy,the control group was given rinse treatment with saline whereas the trial group was given Yinlian Gargle.The incidence of severe acute radiation-induced oropharyngeal mucositis,the duration and intensity of oropharyngeal discomfort and pain(NRS score),quality of life(QOL-NPC score),duration and intensity of radiation-induced side effects(SE-QOL-NPC score)and symptoms of dry mouth(SE1 score)were monitored before and after intervention in two groups.Results The incidence of grade Ⅲ or above radiation-induced oropharyngeal mucositis until the sixth week of radiotherapy in the trial group was considerably lower than that in the control group(P＜0.001),while the incidence of grade I or above radiation-induced oropharyngeal mucositis at 1 month after radiotherapy in the trial group was obviously lower than that in the control group(P＜0.001).The NRS score of pharyngeal discomfort of the trial group was lower than that of the control group starting from the second week of radiotherapy(P＜0.05).The NRS score of oral and oropharyngeal pain was lower than that of the control group starting from the fourth week of radiotherapy(P＜0.05).The SE1 score of the trial group was higher than that of the control group starting from the fifth week of radiotherapy(P＜0.05).After one month of the completion of the radiotherapy,the NRS score of pharyngeal discomfort and the NRS score of oral and oropharyngeal pain in the trial group were lower than those of the control group(P＜0.001).The QOL-NPC score,SE-QOL-NPC score,and SE1 score were all higher than those in the control group(P = 0.05 or P＜0.05).Conclusion Patients with nasopharyngeal cancer can greatly reduce their risk of developing severe acute radiation-induced oropharyngeal mucositis,effectively delay and relieve related symptoms,and enhance quality of life by consistently using Yinlian Gargle during radiotherapy.Additionally,a month after the completion of radiotherapy,it still has positive therapeutic effects on acute radiation-induced oropharyngeal mucositis.

Yinlian Garglenasopharyngeal carcinomaacute radiation-induced oropharyngeal mucositisclinical effects

方彩珊、肖佩琪、钟毓、汪咏春、张驰名、周敏、闫亚杰、阮岩

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广州中医药大学第一临床医学院,广东 广州 510405

成都中医药大学附属医院,四川 成都 610000

广州中医药大学第一附属医院,广东 广州 510405

中山大学附属第三医院过敏科,广东 广州 510630

广东省中医临床研究院岭南耳鼻喉病研究所,广东 广州 510405

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银连含漱液 鼻咽癌 急性放射性口咽黏膜炎 临床疗效

国家自然科学基金面上项目国家自然科学基金面上项目广东省基础与应用基础研究基金区域联合基金-青年基金广州市科技基础与应用基础研究一般项目(博士青年科技人员类)

82274590819745812021A1515110446202201011211

2024

10.19378/j.issn.1003-9783.2024.01.016

中药新药与临床药理
广州中医药大学

中药新药与临床药理

CSTPCD北大核心
影响因子：0.908
ISSN：1003-9783
年,卷(期)：2024.35(1)
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