丹参活性成分抗膝骨关节炎的药理研究进展
Advances in Pharmacological Research on Anti-knee Osteoarthritis of Active Components of Salviae Miltiorrhizae Radix et Rhizoma
傅永升 1王卫国 2张城铭1
作者信息
- 1. 山东中医药大学,山东 济南 250013
- 2. 山东中医药大学,山东 济南 250013;山东中医药大学附属医院,山东济南 250014
- 折叠
摘要
膝骨关节炎(knee osteoarthritis,KOA)作为一种退行性骨关节疾病,其发病率较高,已严重影响中老年人的生活质量.丹参作为一种常用的活血祛瘀中药,经基础研究及临床应用已证实对KOA有一定的防治效果.研究发现,丹参活性成分具有调控炎性因子、抗氧化应激、抑制软骨细胞凋亡、调节软骨基质降解、促进软骨细胞自噬等多种抗KOA的作用,能够减轻关节疼痛、炎性水肿,延缓关节软骨退变,维持软骨基质稳态.该文综述了丹参有效成分防治KOA的作用及其机制,并分析其相关研究存在的不足,可为KOA的临床治疗提供参考.
Abstract
Knee osteoarthritis(KOA)is a degenerative joint disease with a high incidence,which has seriously affected the quality of life of middle-aged and elderly people.Salviae Miltiorrhizae Radix et Rhizoma,a commonly used traditional Chinese medicinal for activating blood and removing stasis,has been proved to have a certain preventive effect on KOA in basic research and clinical application.Studies have found that the active ingredients of Salviae Miltiorrhizae Radix et Rhizoma have a variety of anti-KOA effects,such as regulation of inflammatory factors,anti-oxidative stress,inhibition of chondrocyte apoptosis,regulation of cartilage matrix degradation,and promotion of chondrocyte autophagy.It can reduce joint pain and inflammatory edema,delay articular cartilage degeneration,and maintain cartilage matrix homeostasis.This paper reviews the effect and mechanism of the effective components from Salviae Miltiorrhizae Radix et Rhizoma on the prevention and treatment of KOA,and analyzes the shortcomings of its related research.Our aim is to provide reference for the clinical treatment of KOA.
关键词
丹参/活性成分/膝骨关节炎/炎性因子/软骨退变/作用机制Key words
Salviae Miltiorrhizae Radix et Rhizoma/active ingredients/osteoarthritis/inflammatory factors/cartilage degeneration/mechanism of action引用本文复制引用
基金项目
中国中医药研究促进会项目(2021年第18号)
山东省中医药科技项目(2021M173)
济南市临床医学科技创新计划(202019115)
出版年
2024
国家科技期刊平台
NSTL
万方数据