Advances in Pharmacological Research on Anti-knee Osteoarthritis of Active Components of Salviae Miltiorrhizae Radix et Rhizoma
Knee osteoarthritis(KOA)is a degenerative joint disease with a high incidence,which has seriously affected the quality of life of middle-aged and elderly people.Salviae Miltiorrhizae Radix et Rhizoma,a commonly used traditional Chinese medicinal for activating blood and removing stasis,has been proved to have a certain preventive effect on KOA in basic research and clinical application.Studies have found that the active ingredients of Salviae Miltiorrhizae Radix et Rhizoma have a variety of anti-KOA effects,such as regulation of inflammatory factors,anti-oxidative stress,inhibition of chondrocyte apoptosis,regulation of cartilage matrix degradation,and promotion of chondrocyte autophagy.It can reduce joint pain and inflammatory edema,delay articular cartilage degeneration,and maintain cartilage matrix homeostasis.This paper reviews the effect and mechanism of the effective components from Salviae Miltiorrhizae Radix et Rhizoma on the prevention and treatment of KOA,and analyzes the shortcomings of its related research.Our aim is to provide reference for the clinical treatment of KOA.
Salviae Miltiorrhizae Radix et Rhizomaactive ingredientsosteoarthritisinflammatory factorscartilage degenerationmechanism of action
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