Exploration of Syndrome-Treatment and Prescription-Drugs as Well as Possible Mechanisms for Traditional Chinese Medicine in Treating Dengue Based on Retrospective Analysis and Network Pharmacology
Objective To explore the law of syndrome differentiation and treatment of traditional Chinese medicine(TCM)for the treatment of dengue by retrospective analysis and network pharmacology methods.Methods Hospitalized dengue patients in The First Affiliated Hospital of Guangzhou University of Chinese Medicine from 2014 to 2020 were taken as the research objects.TCM syndromes and prescriptions of dengue were excavated through cluster analysis and factor analysis.Then secondary syndrome differentiation and frequency statistics of research objects were conducted.Network pharmacology was utilized to explore the potential mechanisms of TCM.Results There were three syndromes of dengue:"wind-heat complicated with dampness,pathogen in wei qi"syndrome,"damp-heat damaging collaterals,pathogen invading ying blood"syndrome and"lung and spleen qi deficiency,residual pathogen remaining"syndrome,which were ordered from high to low according to the frequency.A total of three new formulas had been excavated.Dengue NO.1 could dispel wind,clear heat,and eliminate dampness,while Dengue NO.2 was good at clearing heat,resolving toxins,and expelling wind and dampness.Dengue NO.3 was good at clearing heat,removing dampness,cooling blood,and stanching bleeding.The three new formulas might contain quercetin and luteolin,which might act on TNF,IL6,AKT1,and might play a therapeutic role through AGE-RAGE signaling pathway in diabetic complications,the positive regulation of protein serine/threonine kinase activity,etc..Conclusion Three syndromes of dengue and three new formulas are discovered in this study.Three new formulas may have viral inhibitory effects and be related to inflammation,immunity,and apoptosis regulation,but each has its own differences.
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