Analysis of Establishing Animal Model of Ovarian Dysfunction with Tripterygium Wilfordii Preparation Based on Literature Mining
Objective To study the published literature on establishing animal models of ovarian dysfunction with tripterygium wilfordii preparation for past 20 years,and to provide data reference for establishing animal models of ovarian dysfunction with tripterygium wilfordii preparation in the future.Methods A search in Chinese Biomedical Literature Database,VIP Journal Chinese Service Platform,Wanfang Data Knowledge Service Platform,Chinese Knowledge Infrastructure,Springer,Embase,Web of Science,Cochrane Library and PubMed databases were conducted,and the published literature related to the topic of the article from 2000 to 2023 was obtained.After careful manual reading and screening,the data including model type,experimental animal type,initial age,screening standard of animals before formal experiment,dosage,administration period,modeling standard and detection index were entered into the database for statistical analysis using Excel 2021 software.Results A total of 278 articles were included,including 270 Chinese articles and 8 English articles.The most common ovarian dysfunction models established by tripterygium wilfordii preparation in the included literature are:premature ovarian failure(POF,96 times,34.53%),ovarian function reserve decline(DOR,80 times,28.78%),and premature ovarian insufficiency(POI,27 times,9.71%).Sprague Dawley(SD)rats(205 times,73.74%),Wistar rats(22 times,7.91%)and Kunming mice(21 times,7.55%)were used as experimental animals.The vaginal exfoliated cells of experimental animals were used to detect the estrous cycle of animals before the start of most experiments.Tripterygium wilfordii polyglycoside suspension was used to establish the animal model,and the dosage was 50 mg·kg-1(121 times,43.53%),75 mg·kg-1(47 times,16.91%)and 40 mg·kg-1(41 times,14.75%).The successfully modeled animals often appeared the disorder of estrous cycle.The detected indicators of high frequency is serum sex hormone(229 times,25.87%).Conclusion Mature female SD rats aged 7-12 weeks with regular estrous cycle are often used to establish the existing animal models of ovarian dysfunction induced by tripterygium wilfordii preparation.The evaluation indexes of the model suggest that estrous cycle,serum sex hormones,ovarian and uterine organ indexes and ovarian histopathology should be integrated.However,there is still a lack of comparison of different modeling methods and the establishment of specific parameters used in modeling,which needs further exploration.
tripterygium wilfordiiovarian injuryanimal modelliterature miningbasic research
NETL
NSTL
万方数据
