Analysis on Chemical Composition and Constituents Absorbed in the Blood of Shenling Baizhu San by UPLC-Q-TOF-MS/MS
Objective To study the chemical composition of Shenling Baizhu San and the components in rat plasma after intragastric administration of Shenling Baizhu San.Methods UPLC-Q-TOF-MS/MS was used for the analysis.According to the retention time,relative molecular weight and secondary ion fragments,as well as reference substance and literature data,the chemical composition and constituents absorbed in the blood of Shenling Baizhu San were identified by using Peak View 1.2 and Chem Draw software.Results A total of 104 chemical components were identified from Shenling Baizhu San,mainly contained flavonoids and organic acids.There were 27 components in rat plasma found after intragastric administration of Shenling Baizhu San,including of 11 prototype components and 16 metabolites.The main metabolic pathway was phase-Ⅱ metabolic pathway.Conclusion In this study,the chemical composition and constituents absorbed in the blood of Shenling Baizhu San were rapidly analyzed by UPLC-Q-TOF-MS/MS technology,which provided a reference for further elucidating the pharmacodynamic substance basis and mechanism of Shenling Baizhu San.
Shenling Baizhu Sanchemical componentconstituents absorbed in the bloodmetabolitesUPLC-Q-TOF-MS/MS
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