首页|基于"血水同病"理论探讨中药调控子宫内膜异位症炎症微环境的研究进展

基于"血水同病"理论探讨中药调控子宫内膜异位症炎症微环境的研究进展

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子宫内膜异位症(Endometriosis,EMs)是一种炎症性疾病,炎症微环境是其发生发展的关键环节.中医学认为"血水同病",即湿瘀互结是EMs的关键病机,炎症微环境是EMs湿瘀状态的体现,正气不足导致水湿内生,瘀血停滞是湿瘀互结状态形成的基础.从现代分子生物学阐释EMs的发病机制,巨噬细胞调控的炎症微环境是"湿"形成的基础,巨噬细胞参与的血管生成是"血瘀"形成的关键.探讨EMs炎症微环境与"血水同病"理论的微观联系,有助于从新的视角阐明EMs的中医病机内涵;以巨噬细胞为靶点,可为EMs的中医证治提供有益参考.
Research Progress on the Regulation of Inflammatory Microenvironment of Endometriosis by Chinese Medicine Based on the Theory of"Same Disease of Blood and Water"
Endometriosis(EMs)is a chronic inflammatory disease.It has been proved that inflammatory microenvironment is the key role in EMs occurance and development.Chinese medicine posits that the theory of"same disease of blood and water",which generally refers to"intermingling dampness and blood stasis",serves as a crucial pathogenesis in EMs.The inflammatory microenvironment is the main manifestation of dampness and blood stasis in EMs,while the insufficiency of vital qi results in endogenous dampness.The stagnation of blood stasis serves as the foundation for the formation of intermingling dampness and blood stasis.Based on contemporary theories in molecular biology,the macrophage-mediated inflammatory microenvironment serves as the foundation for the formation of dampness,while the participation of macrophages in angiogenesis is crucial for the formation of blood stasis.Investigating the intrinsic connection between the inflammatory microenvironment in EMs and the theory of"same disease of blood and water"can contribute to a better understanding of the pathogenesis of EMs from a novel perspective.Remodeling of the inflammatory microenvironment in endometriosis by targeting macrophages may provide a new strategy for EMs treatment.

Endometriosisinflammatory microenvironmentmacrophage reprogrammingsame disease of blood and waterintermingling dampness and blood stasisbiological connotation

郑玮琳、符之逸、温丹婷、刘浩、曹立幸

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广东省第二人民医院,广东 广州 510220

广州中医药大学第二临床医学院,广东 广州 511400

广州中医药大学第二附属医院,广东省中医院,广东 广州 510030

子宫内膜异位症 炎症微环境 巨噬细胞重编程 血水同病 湿瘀互结 生物学内涵

国家自然科学基金青年科学基金广东省自然科学基金广东省自然科学基金-粤穗联合青年基金广州市科技局基础与应用基础项目青年基金广东省中医药局科研项目国家中医药局全国中医临床优秀人才研修项目(第五批)

823052952023A15150111092022A15151106972023A04J113020231018国中医药人教函[2022]1号

2024

10.19378/j.issn.1003-9783.2024.06.019

中药新药与临床药理
广州中医药大学

中药新药与临床药理

CSTPCD北大核心
影响因子：0.908
ISSN：1003-9783
年,卷(期)：2024.35(6)
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