调控肝星状细胞糖酵解抗肝纤维化的机制及中医药防治研究进展
Research Progress on the Mechanism of Regulating Glycolysis of Hepatic Stellate Cells Against Liver Fibrosis and the Prevention and Treatment of Traditional Chinese Medicine
郝梦梦 1刘璐 1易浪平 1李双伟 1陈鑫 1杨虹颖 1高铭凰 1莫友胜 1李伟荣 1王奇1
作者信息
- 1. 广州中医药大学科技创新中心,广东 广州 510405
- 折叠
摘要
肝星状细胞(Hepatic stellate cell,HSC)活化是肝纤维化发生发展过程中的关键环节.活化HSC的代谢重编程已成为当前研究的热点,尤其糖酵解的改变是调控HSC活化的重要因素.该文基于HSC活化过程中的代谢重编程,阐述了通过糖酵解调控HSC活化及肝纤维化的机制,并对中药及其活性成分调节HSC糖酵解防治肝纤维化的研究进展进行了综述.肝纤维化是涉及多因素、多通路的复杂病理过程,调节活化HSC的糖酵解为抗肝纤维化药物的研发提供了一种新思路.
Abstract
Hepatic stellate cell(HSC)activation is a key link in the development of liver fibrosis.The metabolic reprogramming of activated HSC has become a hot topic in current research,especially the change of glycolysis is an important factor in regulating HSC activation.Based on the metabolic reprogramming in the process of HSC activation,this paper expounds the mechanism of regulating HSC activation and liver fibrosis through glycolysis,and reviews the research progress of traditional Chinese medicine and its active ingredients in regulating HSC glycolysis to prevent and treat liver fibrosis.Liver fibrosis is a complex pathological process involving multiple factors and pathways.From the perspective of regulating the glycolysis of activated HSC,it can provide a new idea for the development of anti-liver fibrosis drugs.
关键词
肝星状细胞/活化/肝纤维化/糖酵解/代谢重编程/中药/活性成分Key words
hepatic stellate cells/activation/liver fibrosis/glycolysis/metabolic reprogramming/traditional Chinese medicine/active ingredients引用本文复制引用
基金项目
国家自然科学基金面上项目(82274616)
广东省科技计划国际合作项目(2020A0505100052)
广东省基础与应用基础研究基金企业联合基金项目(2022A1515220121)
出版年
2024
NETL
NSTL
万方数据