Quality Evaluation of Songling Xuemaikang Capsules Based on the Hybrid Model Combining QAMS,Weighted TOPSIS and Grey Relational Analysis
Objective To simultaneously determine of shikimic acid,catechin,quercetin,kaempferol,isorhamnetin,3'-hydroxypuerarin,puerarin,3'-methoxypuerarin,daidzin and genistein in Songling Xuemaikang Capsules by quantitative analysis of multi-components by single-marker(QAMS),and to establish fusion model of weighted technique for order preference by similarity to an ideal solution(TOPSIS)and grey relational analysis(GRA)for evaluating the quality of 15 batches of samples.Methods HPLC method was used to calculate the relative correction factor and content of each component,using kaempferol as internal reference.The feasibility of QAMS method was verified by comparing with the measured value of external standard method.The content results were analyzed by chemometrics to explore the quality difference markers of Songling Xuemaikang Capsules.Taking the VIP value of each component as the weight,we performed differential analysis on sample quality through fusion model of weighted TOPSIS and GRA.Results There was no significant difference between the results of QAMS and external standard method.The 15 batches of samples were clustered into three categories.Puerarin,3'-hydroxypuerarin,quercetin,3'-methoxypuerarin and shikimic acid were the quality difference markers of Songling Xuemaikang Capsules.The results of fusion model of weighted TOPSIS and GRA showed that there were some quality differences in Songling Xuemaikang Capsules produced at different times.Conclusion The hybrid model combining QAMS,weighted TOPSIS and GRA can be used for the comprehensive evaluation of the quality of Songling Xuemaikang Capsules.
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