Clinical Observation of Yishen Huoxue Prescription Combined with Epalrestat Tablets in the Treatment of Diabetic Peripheral Neuropathy with Kidney Deficiency and Blood Stasis Type
Objective To investigate the clinical efficacy of Yishen Huoxue Prescription combined with epalrestat tablets in the treatment of diabetic peripheral neuropathy(DPN)patients with kidney deficiency and blood stasis type,and to explore its influence on serum ficolin-3 level. Methods A total of 106 DPN patients with kidney deficiency and blood stasis type were randomly divided into the control group and the observation group,with 53 cases in each group. Both groups were given basic hypoglycemic drugs to control blood glucose,and then the control group was given eparastat tablets orally,the observation group was given Yishen Huoxue Prescription combined with eparastat tablets. The two groups were treated for 12 weeks. The changes of traditional Chinese medicine (TCM) syndrome Fugl-Meyer assessment scale (FMA),Toronto clinical neuropathy scale (TCSS),electromyography of lower limbs parameters,blood glucose,blood lipids,serum nitric oxide (NO),endothelin-1 (ET-1) and ficolin-3 levels were observed before and after treatment,the clinical efficacy and safety of the two groups were evaluated. Results (1) After treatment,the scores of TCM syndrome and TCSS in both groups decreased (P<0.05),while the FMA scores increased (P<0.05). The scores of TCM syndrome and TCSS in the observation group were lower than those in the control group (P<0.05),FMA score was higher than that of control group (P<0.05). (2)After treatment,the motor nerve conduction velocity (MCV)of common peroneal nerve and the sensory nerve conduction velocity (SCV) of sural nerve in bilateral lower limbs of the two groups were significantly higher than those before treatment(P<0.05),the increasing range of the observation group was obviously larger than that of the control group (P<0.05).(3)After treatment,the levels of fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1c),total cholesterol(TC),and triglyceride(TG)in both groups were significantly lower than those before treatment (P<0.05),the decreasing range of the observation group was obviously larger than that of the control group(P<0.05).(4)After treatment,the serum NO levels in both groups were significantly higher than those before treatment (P<0.05),while the levels of ET-1 and ficolin-3 were lower than those before treatment (P<0.05). Moreover,the serum NO level of the observation group was higher than that of control group,the levels of ET-1 and ficolin-3 in serum of the observation group were lower than those in control group(P<0.05).(5)After treatment,the total effective rate was 90.57％ in the observation group,which was significantly higher than that of 73.58％ in the control group(P<0.05).(6)There was no significant difference in the occurrence of adverse reactions between two groups (P>0.05). Conclusion Yishen Huoxue Prescription combined with epalrestat tablets is effective in treating DPN patients with kidney deficiency and blood stasis type,which can effectively regulate the blood glucose and blood lipid levels of the patients,improve the nerve function and conduction velocity of bilateral lower limbs,regulate the vascular endothelial function,and enhance the motor function of the lower limbs.
diabetic peripheral neuropathyYishen Huoxue Prescriptionkidney deficiency and blood stasis typeelectromyogram of bilateral lower limbmotor function of the lower limbsvascular endothelial functionficolin-3
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