Research Progress on the Prevention and Treatment of Alzheimer's Disease for Targeted Regulation of Mitochondrial Quality Control by Traditional Chinese Medicine
Research Progress on the Prevention and Treatment of Alzheimer's Disease for Targeted Regulation of Mitochondrial Quality Control by Traditional Chinese Medicine
Alzheimer's disease (AD) is a common neurodegenerative disease,which is characterized by high prevalence,wide-ranging complications,and heavy social and family burdens. Its pathological features mainly include extracellular deposition in the brain of neuroinflammatory plaques mainly composed of beta amyloid protein(Aβ),and intracellular accumulation of neurofibrillary tangles formed by hyperphosphorylated Tau protein. Recent studies have shown that mitochondrial dysfunction plays a key role in the pathogenesis of AD. The mitochondrial quality control (MQC) system is an important mechanism for maintaining mitochondrial function and structural stability,including mitochondrial biogenesis,mitochondrial dynamics,autophagy,and regulation of calcium homeostasis. Traditional Chinese medicine has demonstrated unique advantages and potential in the prevention and treatment of AD by regulating MQC. Therefore,this article systematically reviews the research progress on targeted regulation of MQC by traditional Chinese medicine for the prevention and treatment of AD,which provides new strategies and directions for the prevention and treatment of AD.
关键词
中医药/线粒体质量控制/阿尔茨海默病/靶向调控/研究进展
Key words
Traditional Chinese medicine/mitochondrial quality control/Alzheimer's disease/targeted regulation/research progress
维普
万方数据