Research Progress on Pharmacological Activity and Mechanism of Higenamine
Higenamine (HG) is a benzyl isoquinoline alkaloid,which was originally isolated from aconite. The pharmacological activity of HG is mainly manifested in cardiotonic effect,vasodilation,antithrombotic effect,alleviation of myocardial ischemia/reperfusion injury,antioxidant,anti-inflammatory,immune regulation,anti-tumor,etc. HG shows potential therapeutic effects on heart failure,shock,arthritis,ischemia/reperfusion injury,depression,and tumors. It is an important issue to strengthen the research on the pharmacological activity and mechanism of HG,which is of great significance for promoting new drug development and clinical application transformation of HG.
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