目的 了解中药对尘肺病的治疗效果.方法 检索2000年12月-2022年6月在国内外医学期刊上发表的中药治疗尘肺病的文献,单纯中药治疗或者中医合并西医治疗为试验组,西医治疗或者安慰剂或者不治疗为对照组.纳入文献17篇,共1 424例尘肺患者,用Review Manager 5.4进行meta分析.结果 试验组与对照组对比,中药治疗能提高患者临床治疗有效率(OR=6.51,95％CI:3.36～12.64),改善临床呼吸症状(OR=3.29,95％CI:2.50～4.31)、明显改善感染肺部阴影(OR=9.75,95％CI:4.89～19.45)、提高肺功能第 1 s 用力呼气量(forced expiratory volume in one second,FEV1)(OR=0.98,95％CI:0.43～1.54)、第 1 s 用力呼气量占用力肺活量百分比(forced expiratory volume in one second/forced vital capacity,FEV1/FVC)(OR=6.82,95％CI:4.90～8.74)和第 1 s 用力呼气容积占预计值百分比(forced expiratory volume in one second/normal expected value,FEV1％)(OR=8.66,95％CI:6.57～10.75)、明显增加 6 min 步行试验(6-minute walking test,6 MWT)(OR=45.71,95％CI:27.21～64.21),差异均有统计学意义(均P＜0.05).结论 中药治疗尘肺病在提高临床治疗有效率、改善临床症状和感染肺部阴影、提高肺功能和增加6MWT等方面有一定优势,但由于纳入研究样本量较少,需要更多高质量研究加以验证.
Meta-analysis of traditional Chinese medicine in the treatment of pneumoconiosis
Objective To understand the therapeutic effect of traditional Chinese medicine on pneumoconiosis.Methods Literature on the treatment of pneumoconiosis with traditional Chinese medicine published in domestic and foreign medical journals from December 2000 to June 2022 was retrieved.The experimental group was treated with traditional Chinese medicine alone or with traditional Chinese medicine combined with western medicine,and the control group was treated with western medicine or placebo or no treatment.Totally 17 literatures were included,including 1 424 cases of pneumoconiosis,and meta-analysis was performed with Review Manager 5.4.Results Compared with the control group,Chinese medicine treatment can improve the clinical treatment efficiency of patients(OR=6.51,95％CI:3.36-12.64),improve clinical respiratory symptoms(OR=3.29,95％CI:2.50-4.31),significantly improve.the shadow of infected lung(OR=9.75,95％CI:4.89-19.45),improve pulmonary function FEV1(OR=0.98,95％CI:0.43-1.54),FEV1/FVC(OR=6.82,95％CI:4.90-8.74)and FEV1％(OR=8.66,95％CI:6.57-10.75),and significantly increase 6MWT(OR=45.71,95％CI:27.21-64.21),the differences were statistically significance(all P＜0.05).Conclusion Traditional Chinese medicine in the treatment of pneumoconiosis has certain advantages in improving the clinical treatment efficiency,improving clinical symptoms and infected lung shadows,improving lung function and increasing 6MWT.However,due to the small sample size of the included studies,more high-quality studies are needed to verify.
Traditional Chinese medicinePneumoconiosisTreatmentSystem assessment
NETL
NSTL
万方数据
