环境内分泌干扰物调控过氧化物酶体增殖物激活受体γ表达与转录激活的研究进展
Research progress on regulation of environmental endocrine disrupting chemicals on the expressions and transactivation of peroxisome proliferator activated receptor γ
曹亚强 1苗轲 2高旭 2俞建霞 3许滋宁 4陈圆圆2
作者信息
- 1. 南通市疾病预防控制中心环放科,江苏南通 226007;中国疾病预防控制中心环境与健康相关产品安全所环境与人群健康重点实验室,北京 100021
- 2. 中国疾病预防控制中心环境与健康相关产品安全所环境与人群健康重点实验室,北京 100021
- 3. 南通市海门区第五人民医院,江苏南通 226100
- 4. 南通市疾病预防控制中心环放科,江苏南通 226007
- 折叠
摘要
越来越多的实验和人群研究发现,环境内分泌干扰物(endocrine disrupting chemicals,EDCs)除了干扰免疫、神经和生殖等系统的正常功能,还能够影响机体正常脂质代谢.EDCs依赖过氧化物酶体增殖物激活受体γ(peroxisome proliferator activated receptor γ,PPARγ)介导脂肪分化是当前研究的热点.本文围绕PPARγ结构特征、生理功能,以及EDCs对PPARγ的表达调控进行综述,旨在为全面评估EDCs的健康风险提供参考.
Abstract
Mounting evidence from experiment and population studies has shown that environmental endocrine chemicals(EDCs)can also affect the normal lipid metabolism of the body,in addition to interfere with the normal function of immune,nervous,reproductive and other systems.The peroxisome proliferator-activated receptor γ(PPARγ)mediated adipose differentiation is a hot topic in EDCs studies.In this review,the structural characteristics,physiological functions of PPARγ,and the regulation of PPARγexpression by EDCs were systemically introduced,intending to provide reference for a comprehensive assessment of the health risks of EDCs.
关键词
内分泌干扰物/核受体/脂质代谢/肥胖Key words
Endocrine disruptors chemicals/Nuclear receptor/Lipid metabolism/Obesity引用本文复制引用
基金项目
国家自然科学基金青年基金(22206178)
出版年
2024
NETL
NSTL
万方数据