职业锰暴露致工人多系统健康损害的研究进展
Research progress on multi-system health damage of worker by occupational manganese exposure
吴云杰 1周伟 2罗淑华 1易超1
作者信息
- 1. 深圳市光明区疾病预防控制中心职业卫生监测部,广东深圳 518106
- 2. 深圳市职业病防治院职业危害评价所,广东深圳 518001
- 折叠
摘要
锰是人类生长、发育和维持健康所必需的微量元素,但长期的职业暴露会造成不利的健康后果.多项研究已经确定了锰暴露与神经系统异常之间关系,但不断有新的研究表明,锰暴露可能与其他器官功能障碍有关.肺是锰吸收的主要器官之一,而肝脏参与了锰吸收后的稳态调节以及经胆汁清除的过程.本文就职业锰暴露的多系统健康损害、暴露生物标志物以及细胞分子机制等方面的研究作一综述,以期为完善锰暴露工人健康监护体系提供科学依据.
Abstract
Manganese is a necessary microelement for human growth,development and health maintenance,but long-term occupational exposure would cause adverse health consequences.Many studies have identified the association between manganese exposure and neurological abnormalities,but some new research suggests that manganese exposure may be related to other organ dysfunction.Lung is one of the main organs for manganese absorption,and the liver participates in the process of stable regulation and clearance process through bile.The article reviews the research on the multi-system health damage,exposure biomarkers and cellular molecular mechanisms of occupational manganese exposure,aim at providing a scientific basis for improving the health monitoring system of manganese exposed workers.
关键词
锰/职业暴露/健康损害Key words
Manganese/Occupational exposure/Health damage引用本文复制引用
基金项目
深圳市光明区科技计划(2020)(2020R01103)
出版年
2024
NETL
NSTL
万方数据