Effect of multiple environmental exposure to PM2.5 in early pregnancy on thyroid hormone levels in pregnant women
Objective To study the relationship between fine particulate matter(PM2.5)exposure and maternal thyroid hormone levels in different environments during early pregnancy.Methods Using daily PM2.5 data from Bortala Mongolian Autonomous Prefecture of Xinjiang Uygur Autonomous Region,the PM2.5 exposure concentration around the early pregnancy address of 145 maternal infant queue pregnant women in Xinjiang was calculated using the Kriging interpolation tool in Arcgis 10.8.The indoor PM2.5 exposure concentration in the early pregnancy was calculated using the ratio of indoor and outdoor particulate matter concentration(I/O value).The PM2.5 exposure concentration in multiple environments was calculated based on different environmental exposure times,and using a generalized linear model to analyze the relationship between PM2.5 exposure concentration in early pregnancy and thyroid hormone levels in cohort pregnant women under different environments.Results The average daily outdoor exposure concentration of PM2.5 in early pregnancy of 145 pregnant women M(P25,P75)was 37(27,39)μg/m3,the daily average indoor exposure concentration of PM2.5 was 23(18,27)μg/m3.The maximum exposure concentration of PM2.5 in the average daily dose(ADD)of multiple environments was 30(24,33)μg/m3,the minimum exposure concentration of PM2.5 was 25(20,29)μg/m3.145 pregnant women had free thyroxine(FT4)levels of 13.2(12.0,14.4)pmol/L,serum free triiodothyronine(FT3)level was 4.5(4.1,4.8)pmol/L,thyroid stimulating hormone(TSH)level was 2.13(1.02,2.13)μIU/mL.The daily average outdoor,indoor,ADD(highest),and ADD(lowest)environmental PM25 exposure concentrations in early pregnancy were all correlated with FT4 levels during pregnancy,with OR(95％CI)of 0.967(0.954-0.979),0.969(0.957-0.980),0.969(0.959-0.980)and 0.969(0.957-0.980),respectively(all P＜0.05).Conclusion Exposure to PM2.5 in outdoor,indoor,and multiple environments during early pregnancy is correlated with FT4 during pregnancy.Early pregnancy is a special stage where the fetal thyroid gland has not yet developed,and should pay special attention to the imbalance of maternal thyroid hormone levels.
Fine particulate matterMultiple exposuresEarly pregnancyThyroid hormone
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