Longitudinal analysis of blood routine in 338 workers exposed to BTEX in a petroleum refining enterprise in Hainan Province from 2020 to 2022
Objective To understand the abnormal rate and trend of blood routine among workers exposed to benzene,toluene,ethylbenzene,and xylenes(BTEX)in the petroleum refining enterprise in Hainan Province from 2020 to 2022,so as to develop effective preventive and control measures for BTEX exposed workers.Methods The study focused on workers who have been exposed to BTEX for 3 consecutive years and have worked for at least 1 year in a petroleum refining enterprise in Hainan Province from 2020 to 2022,and a longitudinal analysis was used to explore the relationship between BTEX exposure and abnormal blood cell count in workers.Results From 2020 to 2022,a total of 338 BTEX exposure workers in a petroleum refining enterprise in Hainan Province underwent health checks for 3 consecutive years,including 302 men and 36 women.From 2020 to 2022,there were statistically significant differences in the levels of white blood cells,platelets,neutrophils,red blood cells,and male'hemoglobin concentration of workers in petroleum refining enterprise among 3 years(all P＜0.05),and the average white blood cell count was increasing year by year,which were 6.71×109/L,7.02×109/L and 7.09×109/L,respectively.The red blood cell abnormality rate among male workers exposed to BTEX in 3 years was 5.63％,3.97％and 12.58％,respectively,and the difference was statistically significant(P＜0.05).There was statistically significant difference in the hemoglobin concentration among females in different age groups(P＜0.05).The red blood cell abnormality rate among male workers increased with working years,which were 3.36％,5.96％and 9.81％(P＜0.05).The hemoglobin concentration and neutrophil abnormality rate in males showed a decreasing trend under different smoking conditions,the abnormal rate of hemoglobin concentration in males under different drinking conditions showed a decreasing trend,and the differences were statistically significant(all P＜0.05).The abnormal rates of neutrophils and platelets in females were higher than those in males,while the abnormal rate of red blood cells in males was higher than that in females,and the differences were statistically significant(all P＜0.05).Conclusion Long term exposure to low concentrations of BTEX has potential toxicity to male erythroid related blood,and a longitudinal study is needed to quantify benzene series measurements in workers exposed to BTEX to confirm the blood toxicity of low-level BTEX exposure.
Petroleum refiningLow concentration BTEXOccupational health examinationLongitudinal data analysis
NETL
NSTL
万方数据
