Investigation on surveillance of Creutzfeldt-Jakob disease in Xicheng District of Beijing
Objective To understand the incidence,epidemiological and clinical characteristics of Creutzfeldt-Jakob disease surveillance cases in Xicheng District of Beijing from 2018 to 2022.Methods According to the National Creutzfeldt-Jakob Case Surveillance Program,the clinical information,epidemiology,laboratory test results and follow-up data of suspected Creutzfeldt-Jakob cases reported by medical institutions in Xicheng District of Beijing from 2018 to 2022 were investigated and analyzed.Results A total of 245 patients were reported to be monitored through the infectious disease surveillance and early warning information system in Xicheng District of Beijing from 2018 to 2022.Among them,145 patients finally met the diagnostic criteria for Creutzfeldt-Jakob disease,including 99 clinically diagnosed cases of sporadic Creutzfeldt-Jakob disease(sCJD),26 suspected cases of sCJD diagnosis,15 confirmed cases of hereditary Creutzfeldt-Jakob disease(gCJD),and 5 fatal familial insomnia(FFI).The monitoring cases were not reported to have time cluster,dispersed in permanent residence and wide occupation distribution.The primary symptom of the case was rapid progressive dementia.Conclusion The cases detected in Xicheng District of Beijing from 2018 to 2022 showed no temporal and spatial aggregation,and were mainly sporadic.The reporting time,occupation distribution and long-term residence of the cases were consistent with the incidence characteristics of sporadic Creutzin-Jakob disease.Surveillance of epidemiological characteristics in the last five years was roughly the same as that from 2014 to 2017,with regular follow-up and health education helping to reduce the risk of secondary infection.
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