首页|2种风险评估模型在化学毒物风险评估中的应用

2种风险评估模型在化学毒物风险评估中的应用

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目的 探索不同风险评估模型在重点职业病危害因素风险评估中的异同点和适用性.方法 采用美国环境保护署非致癌风险评估模型(The Unite States Environmental Protection Agency's non-carcinogenic risk assessment model,EPA 模型)和新加坡有害化学物质职业暴露半定量风险评估模型(Singapore occupational semi-quantitative risk assessment model,新加坡模型)对珠海市工作场所8种重点职业病危害因素进行职业健康风险评估,根据风险评估结果和一致性检验结果判断各种风险评估模型的特点.结果 8种重点职业病危害因素共计检测2 074个样品,其中超标样品15个;2种模型风险定性结果基本一致的重点职业病危害因素有6种,对二甲苯和三氯乙烯的定性结果出现较大差异;EPA模型判定为不可接受风险的样品数为165个,占7.96%,而新加坡模型为5个,占0.24%.Fisher确切概率法对2种模型定性结论一致性的检验结果为P<0.05,Kappa分析结果为K=0.54(P<0.05).结论 EPA模型与新加坡模型对8种重点职业病危害因素的风险评估结果有所差异,新加坡模型评估结果相对更为保守,EPA模型更易得出不可接受风险的评估结果.在实际应用中应结合职业暴露特点,科学的选择职业健康风险评估模型.
Application of two risk assessment models in chemical toxicant risk assessment
Objective To explore the differences and applicability of different risk assessment models in the risk assessment of key occupational hazard factors.Methods The Unite States Environmental Protection Agency's non-carcinogenic risk assessment model(EPA model)and Singapore's semi-quantitative risk assessment model for occupational exposure to hazardous chemicals(Singapore model)were used to assess the occupational health risk of eight major occupational hazards in workplace in Zhuhai City.The characteristics of various risk assessment models were judged according to the results and consistency test.Results A total of 2 074 samples of eight key occupational hazard factors were detected,of which 15 samples exceeded the standard.The qualitative results of the two models were basically consistent in six major occupational hazard factors,while they were different in xylene and trichloroethylen.The samples judged as unacceptable risk by the EPA model reached 165(7.96%)compared to 5(0.24%)by the Singapore model.The Fisher's exact probability method showed result of P<0.05 for testing the consistency of qualitative conclusions between the two models,and the result of Kappa analysis was K=0.54(P<0.05).Conclusions The risk assessment results of eight major occupational hazard factors were different between EPA model and Singapore model.The Singapore model is more conservative,while the EPA model is more likely to draw an unacceptable conclusion.In practical application,the occupational health risk assessment model should be selected scientifically according to the characteristics of occupational exposure.

Risk assessment modelChemical toxicant risk assessmentApplication

王延、顾玥、齐莹莹、陈晓敏、洪佳彬、何金铜

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珠海市第三人民医院职业卫生科,广东珠海 519000

珠海市第三人民医院珠海市职业与心理健康工程技术研究中心,广东珠海 519000

风险评估模型 化学毒物风险评估 应用

2024

职业与健康
天津市疾病预防控制中心 中华预防医学会

职业与健康

CSTPCD
影响因子:0.737
ISSN:1004-1257
年,卷(期):2024.40(23)