Impact of high fluoride exposure on hyperglycemia in Tianjin
Objective To explore the effect of high fluoride exposure on hyperglycemia,and to provide scientific basis for prevention and treatment of hyperglycemia in fluoride poisoning areas.Methods From 2021 to 2022,a total of 826 adults were randomly selected from drinking-water fluorosis areas in Tianjin to conduct questionnaire survey,physical examination,random urine samples and fasting blood sample testing.Logistic regression analysis was used to analyze the influencing factors of hyperglycemia in the high fluoride areas,and the interaction of related influencing factors was analyzed.Results The detection rate of hyperglycemia was 22.88％.There was a statistically significant difference in the detection rate of hyperglycemia between the high-fluoride area and the control area(x2=13.313,P＜0.01).The results of univariate analysis showed that the prevalence of hyperglycemia was related to high fluorine exposure,overweight and obesity,education level,passive smoking,family history of diabetes,hypertension,urinary fluorine level,high cholesterol,high triglyceride and dyslipidemia(all P＜0.05).Multivariate logistic regression analysis showed that after excluding other confounding factors,high fluoride exposure(OR=2.132,95％CI:1.423-3.194),overweight and obesity(OR=1.907,95％CI:1.288-2.823),family history of diabetes(OR=3.555,95％CI:2.048-6.170),hypertension(OR=1.455,95％CI:1.020-2.076)and dyslipidemia(OR=2.085,95％CI:1.469-2.959)were risk factors for hyperglycemia in adults.Interaction analysis showed that there was a multiplicative interaction between high fluoride exposure and dyslipidemia in the development of hyperglycemia(OR=0.468,95％CI:0.230-0.950,P＜0.05).Conclusion High fluoride exposure was likely to increase the risk of hyperglycemia,and there is a multiplicative interaction between it and dyslipidemia on hyperglycemia.
High fluoride exposureHyperglycemiaInfluencing factorsInteraction
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