The effect of Tianma Gouteng Decoction(天麻钩藤饮).on myocardial fibrosis and change of Ang Ⅱ and ALDO in renovascular hypertensive rats
To study the effect of Tianma Gouteng Decoction on myocardial fibrosis and change of Ang II and ALDO in renovascular hypertensive rats. Methods:48 male SD rats were randomly grouped to the sham-operation group, the model group, the captopril group and the Tianma Gouteng Decoction group, 12 every group. From beginning of the fifth week, the rats were treated with drugs and persisted in 8 weeks. Then observed the BP, LVW, LVI and Coll in every group to confirmed the effect of decreasing blood pressure and reversing myocardial fibrosis. At same time, we observed the change of Ang II and ALDO in circulation and cardiac muscle in every group to probe into the mechanism of treatment. Results: After 4 weeks, the blood pressure of the rats of the model group ascended obviously (P<0.001) , left kidney weight(LK) ,LK/RKdescended(P<0.001) and right kidney weight(RK) increased obviously(P <0.001) , these all confirmed that the operation succeed. After 8 weeks of treatment, the blood pressure level of the captopril and the Tianma Gouteng Decoction group decreased to obtain or be close to normal blood pressure( P < 0. 01). The effect of descending blood pressure of captopril is better (P < 0.05 ). In 12 weeks, the LV W, LVI and Coll of the model group were all higher than the sham-operation group (allP<0.01). It showed that left ventricular hypertrophy and myocardial fibrosis appeared. Those indexes all decreased in the captopril and the Tianma Gouteng Decoction group, but there were not distinct difference between the two groups(P > 0.05). After 12 weeks, the level of ALDO and Ang II in plasma of the model group were higher than the sham-operation group obviously (P < 0.001, P < 0.01). Captopril can decreased the level of the Ang II in plasma distinctly(P<0.05) , but ALDO was not affected(P >0.05). Tianma Gouteng Decoction can decreased the level of ALDO and Ang II in plasma at same time( P < 0.01, P < 0. 05 ). The level of ALDO and Ang II in cardiac muscle of the model group were all higher than the sham-operation group obviously( P < 0.001, P < 0.05 ) , captopril only can decreased the level of Ang II (P < 0.05) and that Tianma Gouteng Decoction can affected both ALDO and Ang II(P<0.01,P<0.05). Conclusion: Through the research, we confirmed that Tianma Gouteng Decoction can decrease the blood pressure of the renovascular hypertensive rat and reverse left ventricular hypertrophy and myocardial fibrosis. The effects maybe relate with the decreasing of the level of the ALDO and Ang II in circulation and cardiac muscle.
Tianma Gouteng Decoction(天麻钩藤饮)renovascular hypertensionmyocardial fibrosisALDOAng II
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NSTL
万方数据
维普
