Effects of Mashe Anjin Pills(麻射安金丸)on Lung Function,Inflammatory Factor Levels,and Acute Attack Risk in Patients with Chronic Obstructive Pulmonary Disease Characterized by Airway Mucus Hypersecretion
Objective:To explore the effects of Mashe Anjin Pills(麻射安金丸)on lung function,levels of inflammatory factors,and acute attack risk in patients with chronic obstructive pulmonary disease(COPD)characterized by airway mucus hypersecretion.Methods:From June 2021 to February 2022,118 COPD patients with airway mucus hypersecretion treated in this hospital were enrolled and randomly divided into a control group(n=59)and an observation group(n=59)using a random number table.The control group received acetylcysteine nebuliza-tion,and the observation group received Mashe Anjin Pills in addition to acetylcysteine nebulization.Clinical efficacy,traditional Chinese medicine(TCM)syndrome scores,lung function,inflammatory factor levels,quality of life,activity capacity,and the incidence of adverse re-actions during the treatment period of the two groups were compared.Follow-up observation was conducted for 12 months,and Kaplan-Meier curves were used to illustrate the acute attack risk curve of COPD.Results:After 14 days of treatment,the total effective rate in the observa-tion group was 91.53％,significantly higher than 77.97％in the control group(P＜0.05).TCM syndrome scores in the observation group[expectoration(2.21+0.61),wheezing(2.22±0.48),cough(2.02±0.44),and chest tightness(1.81±0.52)]were significantly lower than those in the control group[expectoration(2.54±0.77),wheezing(2.53±0.46),cough(2.23±0.47),and chest tightness(2.09+0.48)](P＜0.05).Lung function indicators[PEF(332.07+44.21),FEV1/FVC(62.11+4.55),and FEV1(63.29±4.98)]in the ob-servation group were significantly higher than those in the control group[PEF(309.21±42.87),FEV1/FVC(60.01±5.22),and FEV1(60.25±5.37)](P＜0.05).Inflammatory factor levels[TNF-α(10.26±3.01),IL-8(24.11±3.26),and CRP(4.63±1.23)]in the ob-servation group were significantly lower than those in the control group[TNF-α(12.03±3.12),IL-8(26.56±4.36),and CRP(5.24± 1.33)](P＜0.05).The observation group had significantly lower SGRQ scores(18.23±4.01)and higher 6MWT levels(448.58+68.57)than the control group(20.21±3.21 and 422.65±60.21,respectively)(P＜0.05).The incidence of adverse reactions in the observation group was 8.47％,which was not significantly different from 3.39％in the control group(P＞0.05).During the 12-month follow-up,two ca-ses were lost to follow-up in each group,resulting in a final sample size of 57 in both groups.The observation group had a significantly lower risk of acute attack than the control group(Log-rank X2=4.844,P=0.028).Conclusion:Mashe Anjin Pills can reduce inflammatory lev-els,improve lung function,enhance the quality of life and activity capacity,and significantly lower the risk of acute attack in patients with COPD characterized by airway mucus hypersecretion.
NETL
NSTL
万方数据
