首页|风热感冒临床表型组及药物表型组的构建与表型组学研究

风热感冒临床表型组及药物表型组的构建与表型组学研究

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随着中医药现代化的深入发展,新兴科学表型组学(Phenomics)已成为传统中医药融合现代医学的新研究范式。本文提出以中医证候为框架,结合现代医学对证候相关临床表型特征的共识,构建风热感冒临床表型组,并根据方证相应原则,建立大型"病证方"相结合的风热感冒临床表型组及银翘散药物表型组队列,进行多组学集合的表型组学研究的理论和方法。为中医证候的量化诊断和治疗以及临床疗效评价提供客观科学依据,最终实现风热感冒的精准防治。
Clinical Phenome and Pharmacophenome of Fengre(风热)Cold
Amid the modernization of traditional Chinese medicine(TCM),the emerging phenomics has become a new paradigm for the integration of TCM with western medicine.This study described how to construct a clinical phenome of Fengre(风热f)cold(FRC)based on the TCM syndrome and the syndrome-related phenotypic characteristics in western medicine.In addition,a large phenomic cohort of clinical FRC phe-nome and Yinqiaosan(银翘散)pharmacophenome was established according to the TCM principle of prescription corresponding with syn-drome.The phenomics of these cohorts with integrated multi-omic approaches may lay a scientific basis for the quantitative diagnosis and treatment of TCM syndrome and the evaluation of clinical efficacy and ultimately precise prevention and treatment of FRC.

PhenomicsFengre(风热)coldYinqiaosan(银翘散)TCMMetabonomicsPrecision medicine

刘子渝、高晨皓、叶玲玉、段大跃

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西南医科大学附属中医医院,泸州 646099

西南医科大学中医药表型组学研究中心,泸州 646000

银翘散 风热感冒 表型组学 中医药 代谢组学 精准医学

泸州市人民政府-西南医科大学高层次人才(段大跃团队)引进专项资助国家中医药管理局中医药创新团队及人才支持计划项目资助

2019 LZXNYD-P01DUANZYYCXTD-C-202207

2024

中药药理与临床
中国药理学会 四川省中医药科学院

中药药理与临床

北大核心
影响因子:0.996
ISSN:1001-859X
年,卷(期):2024.40(1)
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