Evaluation and Analysis of Animal Models of Post-Stroke Depression Based on the Characteristics of Disease-Syndrome Combination in Traditional Chinese and Western Medicine
Based on the clinical diagnostic criteria of traditional Chinese medicine(TCM)and western medicine for post-stroke depression(PSD),the present study summarized the advantages and disadvantages of animal models of PSD,and analyzed the coincidence between PSD and the clinical disease-syndrome characteristics in TCM and western medicine.The results showed that the animal models of PSD were mainly based on mixed methods,and the model with the highest coincidence of clinical characteristics in TCM and western medicine was induced by middle cerebral artery occlusion(MCAO)+neonatal isolation+chronic unpredictable mild stress(CUMS),which could partially simulate the syn-drome,such as Xueyu(血瘀),Tanyujiaojie(痰瘀交结),and Ganqiyujie(肝气郁结).However,the current modeling methods for PSD are dominated by the pure combination of modeling methods for cerebral apoplexy and depression,and there is a lack of a unified PSD modeling method.Meanwhile,due to the lack of clinical diagnostic criteria and model evaluation criteria for PSD in TCM and western medicine,the modeling methods are still mainly based on diagnostic and model evaluation criteria for depression.Additionally,the models incline towards modern medicine,and those for TCM disease-syndrome combination are few.Therefore,there are some errors in clinical diagnosis and model evaluation of PSD.It is of great significance to improve the clinical diagnosis and model evaluation criteria for PSD in TCM and western medi-cine and prepare PSD animal models conforming to the clinical characteristics of TCM for the exploration of the pathogenesis and treatment of PSD.
NETL
NSTL
万方数据
