从"毒损脑络"理论探讨牙龈卟啉单胞菌与阿尔茨海默病的相关性
Study on the Relationship between Porphyromonas gingivalis and Alzheimer's Disease from the Theory of "Toxin Damaging Brain Collaterals"
徐曼如 1朱月 1陈金鑫 1李捷 1范依然 1秦静波 1伍文彬1
作者信息
- 1. 成都中医药大学附属医院,成都 610072
- 折叠
摘要
阿尔茨海默病(Alzheimer's Disease,AD)是一种与年龄有关的神经变性疾病,是全球老龄化背景下亟待解决的共同问题,迄今为止其发病机制尚未完全明确.近来有研究表示,牙龈卟啉单胞菌(Porphyromonas Gingivalis,P.g)与AD发病有密切关系.本文从"毒损脑络"理论出发,结合最近的研究进展,讨论牙龈卟啉单胞菌和AD发生的相关性,为AD等神经退行性疾病的中医治疗提供新思路.
Abstract
Alzheimer's disease(AD)is an age-related neurodegenerative disease,which is a common problem to be solved urgently under the back-ground of global aging.So far,its pathogenesis has not been completely clear.Recently,studies have shown that Porphyromonas gingivalis(P.g)is closely related to the pathogenesis of AD.This paper,based on the theory of"toxin damaging brain collaterals"and in combination with recent research progress,discussed the correlation between P.g and AD,aiming to provide a new idea for the treatment of AD and other neurodegenerative diseases.
关键词
阿尔茨海默病/牙龈卟啉单胞菌/毒损脑络/神经炎症Key words
Alzheimer's disease/Porphyromonas gingivalis/Toxin damaging brain collaterals/Neuroinflammation引用本文复制引用
基金项目
国家自然科学基金(82174358)
四川省中医药局项目(2023MS481)
岐黄学者项目(国中医药人教函2022-256)
出版年
2024
国家科技期刊平台
NSTL
万方数据