Animal Model Analysis of Disseminated Intravascular Coagulation Based on the Characteristics of Clinical Diseases in Traditional Chinese and Western Medicine
The present study analyzed the animal models of disseminated intravascular coagulation(DIC)based on related literature.Specifically,the modeling methods,principles,and model indicators of the DIC models in animals were summarized with the etiology,pathogenesis,and di-agnostic criteria of traditional Chinese medicine(TCM)and western medicine as the starting point,and the fitting degree of the models was e-valuated.The analysis and comparison showed that the models induced by endotoxin,rabbit brain powder infusion,thrombin,tissue factor,and polymer dextran had a high degree of fitting with western medicine(fitting degree ≥ 70％),while the models induced by rabbit brain powder infusion,virus,and compound factor had a high degree of fitting with TCM(fitting degree ≥ 60％).It was clear that in the existing modeling methods,the animal models of DIC induced by rabbit brain powder infusion had a higher degree of fitting with TCM and western medicine.However,the most outstanding problem in the existing animal models was the lack of animal models of TCM Zhenghou(证候)induced by the existing methods.Only the endotoxin-induced model reflected the characteristics of Qizhixueyu(气滞血瘀)in TCM.Other modeling meth-ods,based on the characteristics of western medicine symptoms,were mainly induced by exogenous substances and were single in the form,which failed in embodying the pathogenesis of DIC comprehensively.The primary diseases that were easy to cause DIC in the diagnostic crite-ria and some apparent indicators,such as dizziness,tinnitus,and dry eyes,were also difficult to be reflected in models.Therefore,this study pointed out the problems in the modeling and proposed suggestions for improving the DIC models in animals and solving the problems of the single modeling method and lack of models reflecting TCM Zhenghou,thereby promoting the clinical research on DIC.
disseminated intravascular coagulationclinicalanimal modeltraditional Chinese and western medicinecombination of disease and symptom
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