Chinese Medicine in the Treatment of Chronic Kidney Disease by Regulating Mitophagy and Mitochondrial Apoptosis through mTOR Signaling Pathway:A Review
Chronic kidney disease(CKD)arises from many heterogeneous disease pathways that alter the function and structure of the kidney irre-versibly,over months or years.At the moment,no specific drug is available.As a central regulator of intracellular synthesis and catabolism,mTOR signaling pathway modulates autophagy and apoptosis,which plays a key role in the homeostasis and energy metabolism of renal cells.Many a scholar is exploring therapies for chronic diseases via the mTOR signaling pathway from the perspective of molecular biology.Accu-mulating evidence has shown that Chinese medicine is effective for CKD and that Chinese medicine regulates mTOR signaling pathway and the downstream mitochondrial autophagy and apoptosis.The autophagy-apoptosis balance coincides with thought of"harmony"in Chinese medi-cine.Thereby,this study summarized the research on compound Chinese medicine prescriptions,Chinese medicinals,and Chinese medicine extracts in the prevention and treatment of CKD by regulating mitochondrial autophagy and apoptosis through the mTOR signaling pathway,which is expected to serve as a reference for mTOR signaling pathway as a target of Chinese medicine.
Chinese medicineChronic kidney disease(CKD)mTOR signaling pathwayMitophagyApoptosis
NETL
NSTL
万方数据
