Neuroendocrine Correlation of Uyghur Medicine Munziq and Musil for Salty Mucinous Psoriasis
Objective:To investigate the neuroendocrine correlation of Uyghur medicine Munziq and Musil for salty mucinous psoriasis and to pro-vide a basis for Uyghur medicine treatment of the disease.Methods:Thirty-seven clinically hospitalized patients with salty mucinous psoriasis were included in this study,and the symptom indicators before and after the administration of Munziq and Musil were evaluated.And healthy volunteers served as controls to analyze the serum corticotropin-releasing hormone(CRH),adrenocorticotropic hormone(ACTH),cortisol,5-hydroxytryptamine(5-HT),and dopamine(DA)in patients before and after treatment.Results:Before treatment,the occurrence rate of pri-mary symptoms was 100％,and that of secondary symptoms was 82.5％among the patients.After Munziq treatment,the occurrence rates of primary and secondary symptoms decreased to 32.5％and 35.6％,respectively.Following Musil treatment,these rates further decreased to 7.5％and 9％,respectively.In all treatment stages,scores for the Psoriasis Area and Severity Index(PASI),Dermatology Life Quality Index(DLQI),and Physician Global Assessment(PGA)were lower than those before treatment(P＜0.05).The total effectiveness rate was 89.1％after Munziq treatment and 97.3％after Musil treatment.Munziq treatment decreased ACTH(P＜0.05),while Musil treatment re-duced ACTH,Cortisol,CRH,5-HT,and DA compared with the conditions before treatment(P＜0.05),with DA being lower using Musil than Munziq(P＜0.05).Three patients experienced mild side effects such as diarrhea,bloating,and nausea after Musil treatment,which resolved without medication.Routine blood and urine indicators,as well as liver and kidney functions remained within normal ranges before and after treatment.Conclusion:The primary and secondary symptoms of salty mucinous psoriasis significantly improved after Munziq and Musil treat-ment,particularly with the latter.This improvement correlated with the regulation of neuroendocrine factors restoring the patient's internal ho-meostasis.No allergic reactions or adverse effects were reported during the observation period.
Uyghur medicinePsoriasisMunziqMusil5-HydroxytryptamineCorticotropin-releasing hormoneNeuroendocrine system
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