External Use Characteristics of 42 Toxic Chinese Medicinals in Chinese Pharmacopoeia(2020)
Objective:This study aims to summarize the methods and characteristics of external use of toxic Chinese medicinals,clarify the safe dose range of them,and standardize the external use,so as to shorten the treatment cycle and reduce the occurrence of toxic reactions.There-by,this study is expected to serve as a reference for clinical use of toxic Chinese medicinals.Methods:Articles on clinical external use of toxic Chinese medicinals were retrieved,and the main indications,doses,shaping methods and dosage forms,treatment cycle,contraindica-tions,adverse reactions,and solutions were summarized.Results:A total of 42 toxic Chinese medicinals for external use are applied in the form of paste,and mature vinegar,honey,and ginger juice are the main excipients.They are generally applied once a day for 2～3 weeks.The doses of the common toxic Chinese medicinals such as Gansui(甘遂),Zhitiannanxing(制天南星),Liuhuang(硫黄),Zhichuanwu(制川乌),Baifuzi(白附子),Mubiezi(木鳖子),Yuanhua(芫花),Zhicaowu(制草乌),are all higher than the safe oral doses in Chinese Phar-macopoeia,and the external dose of Zhusha(朱砂)is up to 10 g.The adverse reactions generally occur in gastrointestinal tract,accompanied by dizziness,cold sweating,and nausea.In the external application,Qingfen(轻粉)and Langdu(狼毒)induce rash and other adverse reac-tions.Chansu(蟾酥),Jinqianbaihuashe(金钱白花蛇),and other animal medicinals cause adverse reactions in the nervous system,which should be used with caution.Conclusion:The external use of toxic Chinese medicinals is bound to be safer than the internal use.Through data analysis,this paper expounds the characteristics and methods of clinical application of toxic Chinese medicinals,and defines the safe dose range of toxic Chinese medicinals for clinical external use.In view of the safety and the efficiency in the treatment,external use of toxic Chi-nese medicinals has good prospect and should be further studied.
Toxic Chinese medicinalsExternal useExternal treatmentChinese PharmacopoeiaAdverse reactions
万方数据
维普
