Objective:To study the effects of Xingqinganke(杏芩感咳)Granules,including cough and asthma relieving,anti-inflammation,anti-al-lergy,and immune-regulation,so as to provide an experimental basis for further clinical research.Methods:The cough model of mice was in-duced by ammonia,and the cough model of the guinea pig was induced by citric acid.The model of mice with acute lung inflammation was in-duced by lipopolysaccharides.The model of mice with airway hyper-responsiveness and the model of mice with passive skin allergy were in-duced by ovalbumin.Phenol red tracheal secretion experiment,xylene-induced ear swelling test,and lymphocyte proliferation test of mice were performed.Animals were orally administrated with an aqueous solution of Xingqinganke Granules,and then experimental indicators were de-tected to evaluate the effects of Xingqinganke Granules.Results:Compared with that in the blank control group,the number of coughs was re-duced in the Xingqinganke Granule group,and the cough incubation period and asthma incubation period were significantly increased.The se-cretion of phenol red in the airway was increased,and the ear swelling rate was reduced.The locus caeruleus diameter induced by skin allergy was greatly reduced,and the proliferation of splenic lymphocyte,B lymphocyte,and T lymphocyte was enhanced significantly(P＜0.05 or P＜0.01).Compared with those in the model control group,the lung index,degree of edema in lung tissue,and MDA content were reduced in the Xingqinganke Granule group,and the structural destruction in lung tissue and the infiltration of inflammatory cells were improved.The airway resistance was greatly reduced,and the bronchospasm,contraction,emphysema,and infiltration of inflammatory cells around the trachea and blood vessels were improved(P＜O.05 or P＜0.01).Conclusion:Xingqinganke Granules have the effects of cough and asthma relieving and phlegm elimination,and they can inhibit the oxidative stress response of lung tissue,thereby reducing lung inflammation response.They also have anti-allergic and anti-inflammatory effects and can enhance the cellular immunity and humoral immunity of the body by inhibiting bron-chiolar spasms in the lung and improving pulmonary ventilation function.
Xingqinganke(杏芩感咳)GranulesPharmacodynamicsPost-infectious coughanti-inflammationAntiallergicRelieve a coughRelieving asthmaPhlegm elimination
NETL
NSTL
万方数据
