Efficacy and Safety of Yixinshu(益心舒)Capsule in Treatment of Angina Pectoris in Coronary Heart Disease:A Meta-Analysis
Objective:To systematically evaluate the efficacy and safety of Yixinshu(益心舒)Capsule combined with conventional western medi-cine in the treatment of angina pectoris in coronary heart disease.Methods:Databases such as China National Knowledge Infrastructure(CNKI),Wanfang Data,VIP,SinoMed,PubMed,Web of Science and The Cochrane Library were retrieved from the inception to December 2021.And the clinical randomized controlled trials(RCTs)of Yixinshu Capsule combined with conventional western medicine in the treat-ment of angina pectoris in coronary heart disease were included according to the inclusion and exclusion criteria.Meta-analysis was performed using Review Manager 5.3.Results:A total of 22 RCTs were included,involving 3 238 patients.The Meta-analysis showed that Yixinshu Capsule combined with conventional western medicine exhibited effects in the following aspects:improving the clinical efficacy[RR=1.20,95％CI(1.15,1.25)],reducing the frequency of angina pectoris[MD=-1.56,95％CI(-2.42,-0.70)],shortening the duration of angina pectoris[MD=-1.26,95％CI(-1.87,-0.65)],enhancing the efficacy of electrocardiogram[RR=1.19,95％CI(1.10,1.29)],relieving the clinical symptoms[including chest pain[RR=1.15,95％CI(1.07,1.24)],chest tightness[RR=2.52,95％CI(1.58,4.02)],palpitation[RR=1.30,95％CI(1.19,1.41)],weakness[RR=1.42,95％CI(1.19,1.69)],and shortness of breath[RR=1.35,95％CI(1.26,1.44)]],improving heart rate[MD=-3.66,95％CI(-6.61,-0.71)],systolic blood pressure[MD=-4.60,95％CI(-9.55,0.35)]and dias-tolic blood pressure[MD=-1.14,95％CI(-2.43,0.14)],regulating serum total cholesterol(TC)[MD=-0.87,95％CI(-1.46,-0.28)]and triacylglycerol(TG)[MD=-0.19,95％CI(-0.41,0.02)],increasing high-density lipoprotein cholesterol(HDL-C)[MD=0.31,95％CI(0.25,0.37)],and decreasing low-density lipoprotein cholesterol(LDL-C)[MD=-0.71,95％CI(-1.09,-0.34)].There was no significant difference in the incidence of adverse reactions between the experimental group and the control group.Conclusion:Yixinshu Capsule com-bined with conventional western medicine has a certain clinical effect in the treatment of angina pectoris in coronary heart disease,which is worthy of clinical verification by physicians.
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