基于中西医临床病证特点的硅肺病动物模型分析
Animal Models of Silicosis Based on Clinical Symptoms in Chinese and Western Medicine
宫欢欢 1许伟 1祝红 1李秀敏 1苗明三1
作者信息
摘要
为复制高度模拟临床发病机制、具有较高临床吻合度的动物模型,探究硅肺病病变发生发展的全过程,促进硅肺病更深入的研究,笔者在归纳总结现有硅肺病动物模型的基础上分析各模型造模方法、机制及优缺点,评价临床吻合度,发现气管暴露法、气管灌注法及雾化吸入法吻合度较高,造模方法多为西医造模方法且其基本未涉及中医因素.硅肺病动物模型多符合西医诊断标准及临床症状,明显体现中医证型的临床表现很少提及,这使得从实践中积累经验所得的中医知识无法获得理论支撑与发展,因此探究高模拟度高吻合度、体现中医证型的硅肺病动物模型是今后研究的一个重要方向.
Abstract
The establishment of the animal models that highly mimic the clinical pathogenesis and symptoms helps to explore the entire process of the occurrence and development of silicosis and facilitate the in-depth research on silicosis.We introduced the available animal models of sili-cosis from modeling methods,mechanisms,advantages and disadvantages,and consistency between model and clinical symptoms.The models established with the tracheal exposure,intratracheal instillation,and aerosol inhalation methods had high consistency with clinical symptoms,which are mostly western medicine modeling methods and do not involve Chinese medicine factors.Most of the animal models of silicosis meet the diagnostic criteria and clinical symptoms of western medicine,while their clinical manifestations that reflect TCM syndromes are rarely mentioned.This makes the TCM knowledge gained from the accumulated experience in practice unable to obtain theoretical support and de-velopment.Therefore,the exploring the establishment of the animal models of silicosis that reflects the TCM syndrome is an important direc-tion of future research.
关键词
硅肺病/临床/中西医/病证特点/动物模型Key words
Silicosis/Clinical/Traditional Chinese and western medicine/Disease characteristics/Animal model引用本文复制引用
基金项目
国家中医药管理局标准化项目(GZY-FJS-2020-219)
国家国际合作基地项目(2016-65)
河南省重大公益专项(201300310100)
出版年
2024
国家科技期刊平台
NSTL
万方数据