首页|疏风解毒胶囊治疗慢性阻塞性肺疾病急性加重期的Meta分析及药物经济学评价

疏风解毒胶囊治疗慢性阻塞性肺疾病急性加重期的Meta分析及药物经济学评价

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  • NETL
  • NSTL
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目的:系统评价疏风解毒胶囊(SFJDC)联合西医常规与西医常规治疗慢性阻塞性肺疾病加重期(AECOPD)的临床疗效和经济性。方法:检索中国学术期刊全文数据库(CNKI)、万方数据知识服务平台、维普中文科技期刊数据库(VIP)、PubMed、EM-base数据库，检索日期截至2023年6月，按照纳入与排除标准筛选文献，提取数据，通过Meta分析与成本效果分析法对2种方案治疗慢性阻塞性肺疾病临床疗效和经济性进行评价。结果:临床疗效:疏风解毒胶囊联合方案与常规方案治疗AECOPD总有效率分别为88。43％和73。69％，且安全性无显著差异。经济性:疏风解毒胶囊联合方案与常规方案治疗AECOPD住院与非住院患者总有效率的成本效果分析发现，疏风解毒胶囊联合方案组成本效果比(CER)小于常规方案组，表明疏风解毒联合方案更具有经济性。敏感性分析结果较为稳健。结论:疏风解毒胶囊联合常规方案在治疗AECOPD的临床疗效和经济性方面，都优于常规治疗方案，为优势方案。
Meta-analysis and Pharmacoeconomic Evaluation of Shufeng Jiedu(疏风解毒)Capsules in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Objective:To systematically evaluate the clinical efficacy and cost-effectiveness of Shufeng Jiedu(疏风解毒)Capsules(SFJDC)com-bined with conventional western medicine versus conventional western medicine alone in the treatment of acute exacerbation of chronic ob-structive pulmonary disease(AECOPD).Methods:China National Knowledge Infrastructure(CNKI),Wanfang Data,VIP,PubMed,and EMbase were searched from database inception to June 2023.Following inclusion and exclusion criteria,literature was screened,and data were extracted.Meta-analysis and cost-effectiveness analysis were conducted to evaluate the clinical efficacy and cost-effectiveness of the two treat-ment regimens for AECOPD.Results:Clinical efficacy:The total effective rates of SFJDC combined with conventional therapy and convention-al therapy alone in treating AECOPD were 88.43％and 73.69％,respectively,with no significant difference in safety.Cost-effectiveness:Cost-effectiveness analysis of the total effective rate for hospitalized and non-hospitalized AECOPD patients treated with SFJDC combined ther-apy versus conventional therapy revealed that the cost-effectiveness ratio(CER)of the SFJDC combined therapy group was lower than that of the conventional therapy group,indicating that the SFJDC combined therapy was more cost-effective.Sensitivity analysis results were robust.Conclusion:SFJDC combined with conventional therapy is superior to conventional therapy alone in terms of both clinical efficacy and cost-ef-fectiveness in the treatment of AECOPD,making it an advantageous treatment regimen.

Shufeng Jiedu(疏风解毒)CapsulesMeta-analysisCost-effectiveness analysisAcute exacerbation of chronic obstructive pul-monary disease

任慧君、许晶晶、罗娇、徐敏、杨艳、付昆

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成都市第三人民医院药学部,成都 610014

疏风解毒胶囊 Meta分析 成本效果分析 慢性阻塞性肺病急性加重期

国家自然科学基金资助项目四川省中医药管理局中医药科研专项课题成都市第三人民医院院内科研项目

817037812020JC0009CSY-YN-01-2023-063

2024

中药药理与临床
中国药理学会 四川省中医药科学院

中药药理与临床

北大核心
影响因子：0.996
ISSN：1001-859X
年,卷(期)：2024.40(6)
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