疏风解毒胶囊治疗慢性阻塞性肺疾病急性加重期的Meta分析及药物经济学评价
Meta-analysis and Pharmacoeconomic Evaluation of Shufeng Jiedu(疏风解毒)Capsules in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease
任慧君 1许晶晶 1罗娇 1徐敏 1杨艳 1付昆1
作者信息
- 1. 成都市第三人民医院药学部,成都 610014
- 折叠
摘要
目的:系统评价疏风解毒胶囊(SFJDC)联合西医常规与西医常规治疗慢性阻塞性肺疾病加重期(AECOPD)的临床疗效和经济性.方法:检索中国学术期刊全文数据库(CNKI)、万方数据知识服务平台、维普中文科技期刊数据库(VIP)、PubMed、EM-base数据库,检索日期截至2023年6月,按照纳入与排除标准筛选文献,提取数据,通过Meta分析与成本效果分析法对2种方案治疗慢性阻塞性肺疾病临床疗效和经济性进行评价.结果:临床疗效:疏风解毒胶囊联合方案与常规方案治疗AECOPD总有效率分别为88.43％和73.69％,且安全性无显著差异.经济性:疏风解毒胶囊联合方案与常规方案治疗AECOPD住院与非住院患者总有效率的成本效果分析发现,疏风解毒胶囊联合方案组成本效果比(CER)小于常规方案组,表明疏风解毒联合方案更具有经济性.敏感性分析结果较为稳健.结论:疏风解毒胶囊联合常规方案在治疗AECOPD的临床疗效和经济性方面,都优于常规治疗方案,为优势方案.
Abstract
Objective:To systematically evaluate the clinical efficacy and cost-effectiveness of Shufeng Jiedu(疏风解毒)Capsules(SFJDC)com-bined with conventional western medicine versus conventional western medicine alone in the treatment of acute exacerbation of chronic ob-structive pulmonary disease(AECOPD).Methods:China National Knowledge Infrastructure(CNKI),Wanfang Data,VIP,PubMed,and EMbase were searched from database inception to June 2023.Following inclusion and exclusion criteria,literature was screened,and data were extracted.Meta-analysis and cost-effectiveness analysis were conducted to evaluate the clinical efficacy and cost-effectiveness of the two treat-ment regimens for AECOPD.Results:Clinical efficacy:The total effective rates of SFJDC combined with conventional therapy and convention-al therapy alone in treating AECOPD were 88.43％and 73.69％,respectively,with no significant difference in safety.Cost-effectiveness:Cost-effectiveness analysis of the total effective rate for hospitalized and non-hospitalized AECOPD patients treated with SFJDC combined ther-apy versus conventional therapy revealed that the cost-effectiveness ratio(CER)of the SFJDC combined therapy group was lower than that of the conventional therapy group,indicating that the SFJDC combined therapy was more cost-effective.Sensitivity analysis results were robust.Conclusion:SFJDC combined with conventional therapy is superior to conventional therapy alone in terms of both clinical efficacy and cost-ef-fectiveness in the treatment of AECOPD,making it an advantageous treatment regimen.
关键词
疏风解毒胶囊/Meta分析/成本效果分析/慢性阻塞性肺病急性加重期Key words
Shufeng Jiedu(疏风解毒)Capsules/Meta-analysis/Cost-effectiveness analysis/Acute exacerbation of chronic obstructive pul-monary disease引用本文复制引用
基金项目
国家自然科学基金资助项目(81703781)
四川省中医药管理局中医药科研专项课题(2020JC0009)
成都市第三人民医院院内科研项目(CSY-YN-01-2023-063)
出版年
2024
国家科技期刊平台
NSTL
万方数据