Animal Model Analysis Based on Clinical Disease-Syndrome Characteristics of Sequelae of Pelvic Inflammatory Disease in Traditional Chinese and Western Medicine
The sequelae of pelvic inflammatory disease(SPID)is one of the gynecological diseases that seriously affect the reproductive health and quality of life of women in modern society,which is protracted and intractable.At present,the pathogenesis of SPID is still unknown,and the clinical efficacy is not good.Therefore,it is necessary to promote basic and clinical research on SPID and establish an animal model that is more consistent with the clinical symptoms in traditional Chinese medicine(TCM)and western medicine.This article reviewed the etiology,pathogenesis,clinical characteristics,and diagnostic criteria of SPID,summarized the construction methods and modeling mechanisms of exist-ing SPID models in animals,analyzed the advantages and disadvantages of each model according to the fitting degree score of animal models in TCM and western medicine,and proposed suggestions for improvement.The results showed that the foreign body placement method,phenol mucilage,and mechanical injury combined with the phenol mucilage method were ideal in the establishment of SPID models in western medi-cine.In TCM disease-syndrome models,the Hanshiningjie(寒湿凝结)syndrome and Qizhixueyu(气滞血瘀)syndrome were the most con-sistent with clinical characteristics,which can be used as a reference for the optimization of other models.
Sequelae of pelvic inflammatory diseaseAnimal modelsClinical disease-syndrome characteristics
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